Can Six Flavor Rehmannia Pills Be Used for Children with Favism? - Traditional Chinese Medicine

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Can my child take Liu Wei Di Huang Wan (Six-Ingredient Rehmannia Pill) if they have G6PD deficiency?

Xu Baba, 30~39 year old female. Ask Date: 2023/11/22

Dr. Zhang Weidong reply Traditional Chinese Medicine


Hello, Mr.
Hsu: Although there are certain contraindicated Chinese herbs listed for G6PD deficiency, such as Dan Pi from the Six Flavor Decoction, not everyone will have adverse reactions to these contraindicated herbs.
Clinically, small amounts of Chai Hu-type Chinese herbs have been administered to patients with G6PD deficiency without any discomfort.
Therefore, whether contraindicated herbs will trigger G6PD deficiency can only be said that if there is concern, it is safer not to take them.
Zhang Wei-Dong, Department of Traditional Chinese Medicine, Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2023/11/22

More Info


When considering the use of Six Flavor Rehmannia Pills (Liù Wèi Dì Huáng Wán) for children with Favism (a condition also known as G6PD deficiency), it is essential to approach this matter with caution. Favism is a genetic disorder that affects the red blood cells, making individuals more susceptible to hemolytic anemia when exposed to certain triggers, including specific foods and medications.

Six Flavor Rehmannia Pills are a traditional Chinese medicine formulation that typically contains ingredients such as Rehmannia glutinosa, Cornus officinalis, Dioscorea opposita, Alisma orientalis, Poria cocos, and Moutan peony. This herbal remedy is often used to nourish the kidneys and replenish vital essence, and it is commonly prescribed for conditions related to kidney deficiency, such as fatigue, weakness, and certain types of anemia.

However, the safety and efficacy of herbal remedies in children, particularly those with underlying health conditions like G6PD deficiency, are not well-documented in scientific literature. While the individual ingredients in Six Flavor Rehmannia Pills may not directly contain known triggers for hemolysis in G6PD-deficient individuals, the lack of comprehensive studies on the interactions and effects of herbal formulations in this specific population raises concerns.

It is crucial to note that some herbal ingredients can have varying effects on individuals with G6PD deficiency. For example, certain herbs may contain compounds that could potentially trigger hemolysis or interact negatively with the condition. Therefore, it is advisable to avoid self-medication and to consult a healthcare professional, preferably one knowledgeable in both Western and traditional Chinese medicine, before introducing any new herbal remedies to a child with Favism.

In addition to consulting a healthcare provider, parents should also be vigilant about monitoring their child's diet and avoiding known triggers for hemolytic episodes, such as fava beans, certain legumes, and specific medications. If your child is experiencing symptoms such as fatigue, jaundice, or dark urine, it is essential to seek medical attention promptly.

In summary, while Six Flavor Rehmannia Pills are a commonly used herbal remedy, their use in children with Favism should be approached with caution. Consulting with a healthcare professional is critical to ensure the safety and well-being of your child. It is always best to prioritize evidence-based treatments and to be cautious with herbal remedies, particularly in populations with specific health concerns.

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