Medication Changes and Timing Issues in Cardiovascular Care - Cardiology

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Medication change and schedule adjustment issues?


Director He, regarding the premature contraction issue I mentioned last time, I underwent another 24-hour Holter monitor test, during which I intentionally walked quickly and climbed stairs.
Although I still experienced shortness of breath, coughing, and nausea, along with missed beats, it seems to be within the safe range of missed beats as before? (I might be imagining a possible "subjective or anticipatory psychological effect.") I will continue to consult my physician! Hehe.
This time, I mainly want to ask about medication issues...

1.
I was originally taking one capsule of Lipitor 500/20 mg in the evening, but since my triglycerides remained high at 365, I added one capsule of Pravastatin 4 mg in the morning, which has brought it down to 310 over the past three months (as per medical advice to continue taking it).

2.
The long-term medication, Kady (Carvedilol) 90 mg, is out of stock, so I switched to Entresto (Sacubitril/Valsartan) 120 mg.
I work fixed night shifts, so what is daytime for others is nighttime for me! Previously, I was on a slow-release regimen (according to the medication bag instructions), which included:
Morning: ½ capsule of Quetiapine 50 mg + one Pravastatin capsule (self-arranged as per medical advice, can be taken together or spaced out after meals).

Evening: ½ capsule of Nebivolol 5 mg + Entresto capsule + Lipitor.

In December, the slow-release regimen (according to the medication bag instructions) changed to:
Morning: ½ capsule of Quetiapine 50 mg + ½ capsule of Pravastatin + Entresto capsule.

Evening: ½ capsule of Nebivolol + Lipitor.

My question is whether I can take Quetiapine, Pravastatin, and Entresto together in the morning, or should I space them out? I don't recall the physician mentioning any changes to the medication timing during my last visit.
I hope this description isn't too confusing and doesn't cause you any trouble.
Thank you!

Mr. Zhang, 60~69 year old female. Ask Date: 2023/12/15

Dr. He Dongjin reply Cardiology


Hello, you can take the medication once a day at your convenience; there are no restrictions on whether to take it in the morning or evening.
If you experience no discomfort while taking it together with other medications, that is fine.
Changhua Hospital cares about your well-being.

Reply Date: 2023/12/15

More Info


When it comes to managing cardiovascular health, medication timing and changes can significantly impact treatment efficacy and patient comfort. Based on your detailed account of your medication regimen and the adjustments you've made, let's break down the key points and provide some guidance.


Understanding Your Current Medication Regimen
1. Current Medications:
- Lipid-Lowering Agents: You mentioned taking a combination of medications to manage your triglyceride levels, specifically a statin (理脂) and a fibrate (平脂). It's important to monitor triglyceride levels regularly, especially since your levels were initially high at 365 mg/dL and have now decreased to 310 mg/dL after three months of treatment. This indicates that your current regimen is somewhat effective, but further adjustments may be necessary to reach optimal levels (ideally below 150 mg/dL).


2. Antihypertensive and Heart Rate Control: You are also taking medications like 可悅您 (Carvedilol) and 耐比洛 (Nebivolol), which are beta-blockers that help manage heart rate and blood pressure. The switch from 凯蒂心 (which I assume is another beta-blocker) to 能得爽 (which is likely a different formulation) should be monitored closely, as different formulations can have varying effects on heart rate and blood pressure control.


Timing and Combination of Medications
1. Combination of Medications:
- It is generally safe to take multiple medications together, especially if they serve different purposes (e.g., lipid management and blood pressure control). However, it is crucial to follow your healthcare provider's instructions regarding timing. For instance, some medications may be better absorbed on an empty stomach, while others may require food to minimize gastrointestinal side effects.

- In your case, taking 可悅您 (Carvedilol), 平脂 (Fibrate), and 能得爽 (another medication) together in the morning is acceptable, but it’s advisable to check if any of these medications have specific requirements regarding food intake. If there are no specific instructions from your physician, taking them together should be fine.

2. Spacing Doses:
- If you experience any side effects or if your physician has indicated that certain medications should not be taken together, spacing them out may be beneficial. For example, if you notice increased fatigue or dizziness, it might be worth discussing with your doctor whether to separate the doses of your medications.


Monitoring and Follow-Up
1. Regular Monitoring:
- Since you are on a complex medication regimen, regular follow-ups with your healthcare provider are essential. This includes monitoring your blood pressure, heart rate, and triglyceride levels. If you notice any significant changes in your symptoms, such as increased shortness of breath, palpitations, or any new symptoms, it’s crucial to report these to your physician immediately.

2. Psychological Factors:
- You mentioned the possibility of psychological factors influencing your symptoms, such as anxiety or stress. It’s not uncommon for patients to experience symptoms that may be exacerbated by psychological states. If you feel that anxiety is playing a role, discussing this with your healthcare provider can lead to additional support, whether through counseling or medication adjustments.


Conclusion
In summary, managing cardiovascular health requires careful attention to medication timing and potential interactions. Your current regimen seems to be on the right track, but continuous monitoring and open communication with your healthcare provider are vital. If you have any uncertainties about your medication schedule or experience any adverse effects, do not hesitate to reach out to your physician for clarification and guidance. Your health and comfort are paramount, and your proactive approach to managing your condition is commendable.

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