Fluctuations in glycated hemoglobin (HbA1c) levels within one month?
Hello Doctor: Thank you for taking the time to answer my questions despite your busy schedule.
In my family, besides my parents, my aunts, uncles, and both sets of grandparents have diabetes, so I am particularly concerned about blood sugar levels.
Since mid-August, I have lost weight from 65 kg to only 59 kg now, so I am worried that there might be an issue with my blood sugar causing this weight loss.
Therefore, today I went to a medical laboratory to test my glycated hemoglobin, fasting blood glucose, and fasting insulin, with the following results: Glycated hemoglobin: 5.5%, Fasting blood glucose: 77 mg/dL, Insulin: 5.23 µU/mL.
However, on December 2, I went to another medical laboratory, and the results for glycated hemoglobin and fasting blood glucose were as follows: Glycated hemoglobin: 5.1%, Fasting blood glucose: 89 mg/dL.
During the period from December 2 to December 25, I consumed slightly more sugary foods, including beverages and snacks that are refined carbohydrates.
Additionally, I had a test on September 16 with results: Glycated hemoglobin: 5.4%, Fasting blood glucose: 92 mg/dL.
The difference between these two periods is that on September 16, school had just started, and I had not exercised much during the summer vacation, with a moderate intake of refined carbohydrates.
After school started, I was able to walk almost 6,000 steps daily, and my intake was similar to that during the summer, but my carbohydrate intake in December was somewhat higher.
I would like to ask the doctor: 1.
My insulin resistance calculation (0.994) indicates no issues; what could cause such a significant change in glycated hemoglobin within a month? 2.
Following up on the previous question, could this be due to new red blood cells not being fully formed and a higher intake of refined carbohydrates? 3.
Is my rate of weight loss considered normal? 4.
Should I be concerned about my blood sugar levels? 5.
Given my blood sugar levels, how often should I test my glycated hemoglobin and blood glucose? Thank you, doctor, for answering my questions; I have quite a few, and I appreciate your help.
Zhu, 20~29 year old female. Ask Date: 2023/12/25
Dr. Li Jian reply Internal Medicine
Weight loss can also be evaluated by testing thyroid function.
Currently, there are no significant abnormalities in blood glucose levels, so testing once every 1-2 years is sufficient.
Thank you for your inquiry.
Reply Date: 2023/12/25
More Info
Thank you for your detailed inquiry regarding your blood sugar levels and fluctuations in glycated hemoglobin (HbA1c). It’s great to see that you are actively monitoring your health, especially given your family history of diabetes. Let’s address your questions one by one.
1. Fluctuations in Glycated Hemoglobin: The changes in your HbA1c levels from 5.5% to 5.1% over a month, despite variations in your diet, can be attributed to several factors. HbA1c reflects your average blood glucose levels over the past two to three months, so a single month may not show drastic changes unless there are significant shifts in your blood glucose levels. The slight decrease could be due to improved glycemic control, increased physical activity, or even variations in your red blood cell turnover. If your body is producing new red blood cells more rapidly, it could lead to a lower HbA1c, as newer cells may have been exposed to lower glucose levels.
2. Dietary Impact: Yes, your dietary intake of refined carbohydrates and sugars can influence your blood glucose levels and, subsequently, your HbA1c. Increased consumption of refined carbohydrates can lead to spikes in blood sugar, which may not immediately reflect in your HbA1c but can contribute to overall glucose levels. However, since your HbA1c decreased, it suggests that your overall blood glucose levels may have been well-managed despite occasional indulgences.
3. Weight Loss: A weight loss from 65 kg to 59 kg over a short period can be concerning, especially if it is unintentional. Rapid weight loss can sometimes indicate underlying health issues, including hyperglycemia or other metabolic disorders. Given your family history of diabetes, it is essential to monitor this closely. If you are not actively trying to lose weight and are experiencing this change, it would be wise to consult a healthcare provider to rule out any potential issues.
4. Blood Sugar Concerns: Your fasting blood glucose levels of 77 mg/dL and 89 mg/dL are within the normal range. An HbA1c of 5.5% and 5.1% also indicates good glycemic control. However, given your family history and the recent weight loss, it is prudent to remain vigilant. Regular monitoring and maintaining a balanced diet, along with physical activity, are key to preventing diabetes.
5. Monitoring Frequency: Given your current HbA1c levels and the absence of diabetes, it is generally recommended to check your HbA1c every six months. However, since you have concerns about your weight loss and family history, you might consider having it checked every three months. Regular fasting blood glucose checks can also be beneficial, especially if you notice any changes in your weight or overall health.
In summary, while your current blood sugar and HbA1c levels are within normal limits, the rapid weight loss and family history of diabetes warrant close monitoring. It would be advisable to maintain regular check-ups with your healthcare provider to ensure that any potential issues are addressed promptly. Additionally, focusing on a balanced diet and regular physical activity will help in managing your blood sugar levels effectively. If you have further concerns or notice any additional symptoms, do not hesitate to reach out to your healthcare provider for personalized advice.
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