Why Inderal May Be Losing Its Effectiveness Over Time - Cardiology

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I gradually feel that Inderal is becoming ineffective?


Hello Doctor: I have mitral valve prolapse and tricuspid valve prolapse, and I occasionally experience arrhythmias and increased heart rate due to anxiety.
During my student years, I first took Inderal (I am now in my fifties).
Initially, when I started taking it, I would only take one pill, and it worked very well for both palpitations and arrhythmias.
However, as I have aged and continued long-term use, I have increased my dosage from one pill to three pills at a time.
Gradually, I have noticed that Inderal seems to be less effective for me.
What should I do next? Should I switch medications? I would appreciate your guidance on this matter.
Thank you.

Yu Zai, 40~49 year old female. Ask Date: 2023/12/27

Dr. He Dongjin reply Cardiology


Hello, please discuss adjusting your medication with your attending physician.
Changhua Hospital cares about you.

Reply Date: 2023/12/27

More Info


Inderal, known generically as propranolol, is a non-selective beta-blocker commonly used to manage various conditions, including hypertension, anxiety, and certain types of arrhythmias. It works by blocking the effects of adrenaline on beta receptors, which helps to reduce heart rate and blood pressure, and can also alleviate symptoms of anxiety. However, as you've experienced, the effectiveness of Inderal can diminish over time for several reasons.

One primary reason for the perceived decrease in effectiveness is the development of tolerance. Tolerance occurs when the body becomes accustomed to a medication, requiring higher doses to achieve the same therapeutic effect. This phenomenon is not uncommon with many medications, including beta-blockers. As you age, your body's metabolism and response to medications can change, which may also contribute to this issue. Additionally, the underlying conditions you are managing, such as mitral valve prolapse and tricuspid valve prolapse, may evolve over time, potentially necessitating adjustments in your treatment regimen.

Another factor to consider is the potential for changes in your lifestyle, stress levels, or overall health, which can influence how well Inderal works for you. For instance, increased stress or anxiety levels can exacerbate symptoms, making it seem like the medication is less effective. Furthermore, if you have developed any new medical conditions or are taking other medications, these could interact with Inderal and affect its efficacy.

Given your situation, it is essential to consult with your healthcare provider. They can evaluate your current health status, review your medication regimen, and determine whether a dosage adjustment or a change in medication is warranted. It is crucial not to make any changes to your medication without professional guidance, as abrupt changes can lead to withdrawal symptoms or exacerbate your conditions.

In addition to medication adjustments, your healthcare provider may also discuss non-pharmacological approaches to managing anxiety and heart rhythm issues. Cognitive-behavioral therapy (CBT), relaxation techniques, and lifestyle modifications, such as regular exercise, a balanced diet, and stress management strategies, can be beneficial adjuncts to your treatment plan.

In summary, if you feel that Inderal is losing its effectiveness, it is vital to have an open dialogue with your healthcare provider. They can help you navigate this issue, considering factors like tolerance, lifestyle changes, and potential interactions with other medications. Together, you can develop a comprehensive treatment plan that addresses both your heart health and anxiety symptoms effectively.

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