How Long Should You Take Oral A Acid for Skin Improvement? - Dermatology

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How long should A acid be taken?


Hello, I have been taking oral isotretinoin for three years and four months, at a dosage of 20 mg every other day.
Can I conclude the treatment? I have not experienced any acne symptoms, and my oiliness has also improved.
I weigh 66 kg.

Mr. Wang, 20~29 year old female. Ask Date: 2024/01/12

Dr. Li Yufen reply Dermatology


Hello: The symptoms have improved after taking oral isotretinoin, and I have been on it for three years and four months.
I recommend returning for a follow-up appointment to have the physician assess whether it is still necessary to continue the treatment.
Thank you!

Reply Date: 2024/01/12

More Info


When it comes to the duration of oral A acid (Isotretinoin) treatment for skin improvement, there are several factors to consider. Based on your experience of taking 20 mg every other day for three years and four months, and given that you have not experienced any acne or excessive oiliness, it seems you have made significant progress. However, the decision to discontinue treatment should ideally be made in consultation with a dermatologist.

Oral A acid is a powerful medication primarily used to treat severe acne, particularly cystic acne that does not respond to other treatments. The typical course of treatment can vary widely among individuals, often lasting from four to six months, but some patients may require longer durations depending on the severity of their condition and their response to the medication. The cumulative dose is a critical factor; it is generally recommended to reach a total dose of about 120-150 mg per kilogram of body weight over the course of treatment. For someone weighing 66 kg, this would translate to a total dose of approximately 7920 mg to 9900 mg.
Since you have been on a relatively low dose (20 mg every other day), it is essential to evaluate how much total A acid you have taken during your treatment. If you have not reached the recommended cumulative dose, your dermatologist may suggest continuing the treatment for a bit longer to ensure long-term remission of acne.
Moreover, it is crucial to monitor for any potential side effects, as A acid can have significant adverse effects, including dry skin, lip inflammation, and potential mood changes. If you have experienced any side effects, it is vital to discuss these with your healthcare provider, as they may influence the decision to continue or discontinue the medication.

In terms of skin improvement, many patients notice significant changes within the first few months of treatment, but complete results can take time. It is also important to maintain a good skincare routine post-treatment to prevent any potential relapse of acne. This includes using non-comedogenic products, regular moisturizing, and sun protection, as A acid can make the skin more sensitive to sunlight.

If you are considering stopping the medication, it is advisable to have a follow-up appointment with your dermatologist. They can assess your skin condition, discuss your treatment history, and help determine the best course of action moving forward. They may also recommend a gradual tapering off of the medication rather than an abrupt stop, which can help mitigate any potential rebound effects.

In summary, while your progress is promising, the decision to end your A acid treatment should be made collaboratively with your dermatologist, taking into account your total cumulative dose, skin condition, and any side effects you may have experienced. Regular follow-ups and open communication with your healthcare provider are key to achieving and maintaining healthy skin.

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