Persistent Pain After Injection: Causes and Next Steps - Family Medicine

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The injection site may be painful?


I received an anti-inflammatory injection in my right arm, and it has been two weeks since then.
The injection site still experiences pain, the arm feels sore, and there is slight weakness, although there are no visible abnormalities.
Could you please help me understand the possible reasons for this? Do I need further examination? If so, which specialty should I consult? Thank you.

A Jun, 20~29 year old female. Ask Date: 2024/01/17

Dr. Chen Bozhang reply Family Medicine


Please return for a follow-up appointment with the original treating physician for evaluation, or visit a family medicine clinic for care.
Thank you.

Reply Date: 2024/01/17

More Info


Persistent pain following an injection, such as the anti-inflammatory injection you received in your right arm, can be concerning and may arise from several factors. It is important to understand the potential causes of this pain and the appropriate next steps to take.

Firstly, it is not uncommon for patients to experience some discomfort or pain at the injection site after receiving an injection. This can be due to several reasons:
1. Injection Site Reaction: The body may react to the injection itself, leading to localized inflammation, swelling, or irritation. This is often temporary and should resolve within a few days to a week.

2. Nerve Irritation or Injury: If the injection inadvertently affected nearby nerves, it could lead to persistent pain, tingling, or weakness in the arm. This is particularly relevant if you experienced sharp pain during the injection.

3. Muscle or Tendon Strain: The injection may have caused some strain to the surrounding muscles or tendons, especially if the injection was administered in a manner that required you to tense your arm.

4. Underlying Condition: If there was an underlying condition that prompted the injection, such as tendonitis or bursitis, the pain may persist due to the ongoing nature of that condition, independent of the injection.

Given that you have been experiencing pain for two weeks, it is advisable to take the following steps:
1. Monitor Symptoms: Keep track of your symptoms, noting any changes in pain intensity, location, or any new symptoms that may arise. This information will be helpful for your healthcare provider.

2. Rest and Ice: Resting the affected arm and applying ice to the injection site can help reduce inflammation and alleviate pain. Avoid activities that exacerbate the pain.

3. Consult a Healthcare Provider: If the pain persists or worsens, it is important to seek medical attention. You should consider visiting a physician who specializes in musculoskeletal disorders, such as an orthopedic doctor or a pain management specialist. They can perform a thorough evaluation, which may include a physical examination and possibly imaging studies (like an X-ray or MRI) to rule out any underlying issues.

4. Physical Therapy: If deemed appropriate, your doctor may recommend physical therapy to help strengthen the muscles around the injection site and improve function.

5. Further Investigations: If there is suspicion of nerve involvement or if the pain does not improve, further investigations such as nerve conduction studies or electromyography (EMG) may be warranted to assess nerve function.

In summary, while some pain after an injection can be normal, persistent pain lasting more than a week warrants further evaluation. Consulting with a specialist will help determine the underlying cause of your symptoms and guide you toward appropriate treatment options. Remember, early intervention can often lead to better outcomes, so do not hesitate to seek help if your symptoms do not improve.

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