Do Antipsychotics Make You More Sensitive to Cold? - Psychiatry

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Antipsychotic medications, such as Lurasidone (the active ingredient in Latuda), can indeed have various side effects, and increased sensitivity to cold is one of the potential issues some patients may experience. While not universally reported, this phenomenon can be attributed to several factors related to the pharmacological effects of these medications.

Firstly, antipsychotics can influence the body's thermoregulation. They may affect the hypothalamus, which is the part of the brain responsible for regulating body temperature. When the hypothalamus is impacted, it can lead to an impaired ability to maintain a normal body temperature, making individuals feel colder than they typically would. This is particularly relevant in colder months when the body naturally requires more energy to maintain warmth.

Secondly, antipsychotics can lead to metabolic changes. Some patients may experience weight gain or changes in body composition, which can affect how the body generates and retains heat. A higher body fat percentage can sometimes lead to a feeling of being colder, as fat does not conduct heat as efficiently as muscle. Additionally, if the medication causes sedation or lethargy, this can reduce physical activity levels, further contributing to feelings of coldness.

Moreover, certain antipsychotics can cause side effects such as orthostatic hypotension (a drop in blood pressure when standing up), which can lead to feelings of dizziness and coldness, particularly in the extremities. This is due to reduced blood flow to the skin and extremities, making one feel colder.

It's also worth noting that individual responses to medications can vary widely. Some people may experience increased sensitivity to cold, while others may not notice any change. Factors such as overall health, concurrent medications, and individual metabolic rates can all play a role in how one experiences temperature regulation while on antipsychotic medications.

If you are experiencing significant discomfort due to increased sensitivity to cold while taking Lurasidone, it is essential to discuss this with your healthcare provider. They can evaluate your symptoms in the context of your overall treatment plan and may consider adjusting your medication or exploring additional strategies to help manage this side effect.
In summary, while increased sensitivity to cold can occur with the use of antipsychotics like Lurasidone, it is not a universally experienced side effect. The underlying mechanisms may involve changes in thermoregulation, metabolic alterations, and individual variability. Always consult with your healthcare provider for personalized advice and management strategies.