Timing for Progesterone Use: Key Considerations for Fertility Planning - Obstetrics and Gynecology

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Timing of progesterone administration?


Hello, Doctor.
I would like to inquire about the timing of taking progesterone (Duphaston).
My menstrual period started on January 23, and I began taking ovulation medication for five days starting January 25.
I had a follow-up appointment on February 2.
My doctor initially asked me to return on day 14 (February 5) for a follicle check, but on February 1, I noticed an increase in discharge, so I went in early on February 2.
After the examination, the doctor found a follicle and suggested that I start trying to conceive the next day, February 3.
The doctor also prescribed a 14-day course of progesterone to start "that day" to help thicken the endometrium.
However, that evening, I heard from other friends who are trying to conceive that progesterone can suppress ovulation and should be taken only after ovulation.
I have not taken the medication yet, but I followed the doctor's advice and tried to conceive yesterday.
Over the past two days, I have been using ovulation test strips, but the results have been poor, with almost no second line visible, making it difficult for me to determine if I have ovulated (though my doctor did see a follicle).
Given this situation, when would be the best time to start the medication? I feel quite distressed...
Should I follow my doctor's instructions and start taking it regardless of whether I have ovulated? But if I have not ovulated yet, will it have any negative effects? Thank you for your response.

Niming, 30~39 year old female. Ask Date: 2024/02/05

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, please follow the doctor's instructions.
The main function of progesterone is to increase the thickness of the endometrium and enhance implantation.
Wishing you good health.

Reply Date: 2024/02/05

More Info


When it comes to timing the use of progesterone (often referred to as "luteal phase support") in relation to fertility planning, there are several key considerations to keep in mind. Your situation highlights the importance of understanding the role of progesterone in the menstrual cycle and its impact on conception.

Progesterone is a hormone that plays a crucial role in preparing the uterine lining for implantation of a fertilized egg. It is typically produced by the corpus luteum after ovulation. If pregnancy occurs, progesterone helps maintain the uterine lining and supports the early stages of pregnancy. If pregnancy does not occur, progesterone levels drop, leading to menstruation.

In your case, your doctor has recommended starting progesterone on the same day you are advised to begin trying to conceive, which is a common practice. However, there is some debate about the optimal timing for progesterone supplementation. Some practitioners suggest that progesterone should be started after ovulation has been confirmed, as it can potentially inhibit ovulation if taken too early in the cycle. This is particularly relevant if you are unsure whether you have ovulated, as indicated by your use of ovulation test strips.

Given that your doctor has already identified a mature follicle, it is likely that ovulation is imminent. If your doctor has instructed you to start progesterone on the same day as your planned intercourse, it is generally advisable to follow their guidance. They may have assessed your specific situation and determined that the benefits of starting progesterone immediately outweigh the risks of potentially inhibiting ovulation.

If you are concerned about the timing of progesterone use, it is essential to communicate openly with your healthcare provider. They can provide personalized advice based on your medical history, the results of your ultrasound, and your overall fertility plan. If you feel uncertain about whether you have ovulated, your doctor may suggest monitoring your symptoms or conducting additional tests to confirm ovulation before starting progesterone.

In summary, while there is some variability in practice regarding the timing of progesterone supplementation, following your doctor's instructions is typically the best course of action. They are familiar with your specific circumstances and can provide the most appropriate recommendations. If you have any lingering concerns or questions, do not hesitate to reach out to your healthcare provider for clarification and support. Remember, fertility can be a complex journey, and having a supportive medical team can make a significant difference in your experience.

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