Urticaria Linked to Thyroid Hormone Medications - Internal Medicine

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Thyroid hormone medication can cause urticaria?


Hello, doctor! I had my thyroid removed many years ago, so I have been taking thyroid hormone for years.
My current dosage is one Eltroxin 100 mcg tablet per day.
In recent years, I have frequently experienced hives, and I am unsure if this is related to the medication.
I would like to know if there are other thyroid hormone medications available besides this one.
When I brought this issue up with my doctor, they only mentioned that I could go to another hospital.
If I could know what other medications are available, it might help me identify which hospitals prescribe them, making it easier for me to seek a consultation.

Xiao Xi, 40~49 year old female. Ask Date: 2024/03/01

Dr. Li Jian reply Internal Medicine


There are other thyroid hormones available, but if thyroid function is normal, urticaria caused by thyroid hormones is rare.
Thank you for your inquiry.

Reply Date: 2024/03/01

More Info


Urticaria, commonly known as hives, is a skin condition characterized by raised, itchy welts that can vary in size and can appear anywhere on the body. It can be triggered by various factors, including medications, food, infections, and environmental factors. In your case, you have been taking Eltroxin (levothyroxine), a synthetic form of the thyroid hormone thyroxine (T4), for several years following your thyroidectomy. It is understandable to be concerned about the possibility of this medication contributing to your urticaria.

While Eltroxin is generally well-tolerated, some individuals may experience allergic reactions or side effects that could manifest as skin rashes or hives. However, it is important to note that urticaria can also be idiopathic, meaning that the exact cause is unknown, and it may not necessarily be linked to your medication. Other potential causes of urticaria include stress, infections, and exposure to allergens such as pollen, pet dander, or certain foods.

In terms of alternative thyroid hormone medications, there are a few options available:
1. Liothyronine (Cytomel): This is a synthetic form of triiodothyronine (T3), another thyroid hormone. It is sometimes used in conjunction with levothyroxine or as an alternative for patients who may not respond well to T4 alone.

2. Desiccated Thyroid (Armour Thyroid): This is a natural thyroid hormone replacement derived from porcine thyroid glands. It contains both T3 and T4 and may be preferred by some patients who feel they do not respond adequately to synthetic hormones.

3. Combination Therapy: Some healthcare providers may prescribe a combination of levothyroxine and liothyronine to better manage thyroid hormone levels, especially in patients who experience persistent symptoms despite adequate T4 therapy.

If you suspect that Eltroxin is causing your urticaria, it is crucial to discuss this with your healthcare provider. They may recommend an allergy evaluation or consider switching you to an alternative thyroid medication. It is also advisable to keep a diary of your symptoms, noting any potential triggers, including food, stress, and medication changes, to help identify patterns.

In the meantime, managing urticaria often involves avoiding known triggers, using antihistamines to relieve itching and swelling, and in some cases, corticosteroids for more severe reactions. If your urticaria persists or worsens, seeking a consultation with a dermatologist or an allergist may provide further insights and treatment options.

In summary, while it is possible that Eltroxin could be related to your urticaria, it is essential to explore other potential causes and discuss alternative medications with your healthcare provider. Understanding your condition and treatment options will empower you to make informed decisions about your health.

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