Kidney Health: Concerns About eGFR and Bilirubin Levels - Internal Medicine

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Kidney-related issues?


Hello Doctor, I recently felt inspired to undergo a health check-up, and after receiving the results, I am a bit concerned.
My estimated Glomerular Filtration Rate (eGFR) is only 81.25, but my urine protein level is negative (<30).
I have been monitoring my urination, and aside from the first morning urine being quite foamy (possibly due to the recent low temperatures), I haven't noticed this issue at other times; the bubbles dissipate quickly.
However, my total bilirubin (T-Bilirubin) level is 1.26 mg/dl, which is elevated (normal range: 0.03-1.0 mg/dl), and I'm unsure if this is related.
If I maintain a routine of 30 minutes of aerobic exercise daily, drink plenty of water, and eat a healthy diet, is it possible to improve my eGFR? I'm very worried about the possibility of needing dialysis at my age.

Mian, 20~29 year old female. Ask Date: 2024/03/02

Dr. Zhang Shixin reply Internal Medicine


Hello, the definition of chronic kidney disease (CKD) is a glomerular filtration rate (eGFR) of less than 60 mL/min for more than three months, or the presence of proteinuria, hematuria, or structural abnormalities of the kidneys.
Your eGFR is greater than 60 and there is no protein in your urine, so there is currently no need to be overly concerned about kidney disease.
It is recommended to maintain a healthy diet, exercise regularly, and stay adequately hydrated.
If there are any concerns in your health check report, please consult the testing facility.
Thank you for your inquiry!

Reply Date: 2024/03/02

More Info


Understanding kidney health is crucial, especially when it comes to interpreting laboratory results like the estimated glomerular filtration rate (eGFR) and bilirubin levels. Your eGFR of 81.25 indicates that your kidney function is generally within the normal range, as eGFR values above 60 are typically considered acceptable. However, it is essential to monitor any changes over time, especially if you have concerns about your kidney health.

The eGFR is a calculated estimate of how well your kidneys are filtering blood, and it is derived from your serum creatinine level, age, sex, and race. A value of 81.25 suggests that your kidneys are functioning adequately, but it is on the lower end of the normal range. It is important to note that eGFR can fluctuate due to various factors, including hydration status, muscle mass, and even the time of day when the blood sample was taken.
Your urine protein level being negative is a positive sign, as the presence of protein in urine can indicate kidney damage or disease. The fact that you observe bubbles in your first morning urine could be related to the concentration of urine, especially if you are dehydrated. However, if the bubbles dissipate quickly and you do not have persistent proteinuria, it is less likely to be a cause for concern.

Regarding your bilirubin level of 1.26 mg/dL, which is slightly elevated, it is essential to understand that bilirubin is a byproduct of the breakdown of red blood cells and is processed by the liver. Elevated bilirubin levels can indicate liver dysfunction or issues with bile flow, but they do not directly correlate with kidney function. It is advisable to follow up with your healthcare provider to investigate the cause of the elevated bilirubin, as it may require further evaluation.

To address your concerns about kidney health and the potential for reversing any decline in function, maintaining a healthy lifestyle is key. Regular aerobic exercise, such as 30 minutes of walking or cycling, can improve overall cardiovascular health, which is closely linked to kidney health. Staying well-hydrated is also crucial, as it helps the kidneys flush out toxins and maintain proper function. A balanced diet rich in fruits, vegetables, whole grains, and lean proteins while minimizing processed foods, excessive salt, and sugar can further support kidney health.

In addition to lifestyle modifications, it is essential to monitor your blood pressure and blood sugar levels, as hypertension and diabetes are significant risk factors for kidney disease. Regular check-ups with your healthcare provider can help track your kidney function and catch any potential issues early.

In summary, while your eGFR is within a generally acceptable range, it is important to continue monitoring your kidney health through regular check-ups and maintaining a healthy lifestyle. Addressing the elevated bilirubin level with your healthcare provider is also crucial to ensure that there are no underlying liver issues. With proactive management and lifestyle changes, you can support your kidney health and reduce the risk of progression to more severe kidney disease.

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