Can SLE Patients Safely Take Probiotics for Digestive Issues? - Internal Medicine

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Can individuals with SLE take probiotics?


Hello Doctor, I am a patient with SLE.
Recently, I have been experiencing some digestive issues, including bloating and gastrointestinal discomfort (without abdominal pain, constipation, and with a normal appetite).
I have seen a gastroenterologist and had an abdominal ultrasound.
Can I additionally take probiotics? Currently, I am taking steroids (1.5 tablets per day), quinine (1 tablet per day), mycophenolate mofetil (1 tablet per day), and Bokey (1 tablet per day).

Anne, 40~49 year old female. Ask Date: 2024/03/02

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your inquiry.
I believe it is possible.
The Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare, is here to assist you.

Reply Date: 2024/03/02

More Info


As a patient with Systemic Lupus Erythematosus (SLE), it's understandable to be cautious about any supplements or medications you consider taking, especially when experiencing digestive issues like bloating and gas. Probiotics are often recommended for digestive health, but their safety and efficacy can vary, particularly in individuals with underlying health conditions such as SLE.

Probiotics are live microorganisms that can provide health benefits, particularly for gut health. They are commonly used to help restore the natural balance of gut bacteria, especially after antibiotic use or during episodes of gastrointestinal distress. In general, probiotics are considered safe for most people, including those with autoimmune diseases like SLE. However, there are several factors to consider before starting probiotics.

1. Immune System Considerations: SLE is an autoimmune condition that can affect the immune system. While most probiotics are safe, some strains may not be suitable for immunocompromised individuals. It's essential to choose a probiotic that is specifically formulated for people with autoimmune conditions or to consult with your healthcare provider for recommendations.

2. Current Medications: You mentioned that you are currently taking steroids and other medications. Corticosteroids can suppress the immune system, which may increase the risk of infections, including those from certain probiotic strains. Discussing your current medication regimen with your healthcare provider is crucial to ensure that there are no contraindications or potential interactions.

3. Digestive Symptoms: Since you are experiencing digestive issues, probiotics may help alleviate some of your symptoms. Research has shown that certain probiotic strains can help reduce bloating, gas, and other gastrointestinal discomforts. However, the effectiveness can vary from person to person, and it may take some time to notice improvements.

4. Consulting with Healthcare Providers: Before starting any new supplement, including probiotics, it's always best to consult with your healthcare provider or a specialist familiar with your medical history. They can provide personalized advice based on your specific situation, including the types of probiotics that may be beneficial for you.

5. Monitoring for Side Effects: If you decide to take probiotics, monitor your body’s response closely. While side effects are generally mild, such as gas or bloating, any significant changes in your health should be reported to your healthcare provider immediately.

6. Dietary Considerations: In addition to probiotics, consider incorporating a balanced diet rich in fiber, fruits, vegetables, and fermented foods, which can naturally support gut health. Foods like yogurt, kefir, sauerkraut, and kimchi contain beneficial bacteria that can also aid digestion.

In summary, SLE patients can generally take probiotics safely, but it is essential to choose the right strains and consult with healthcare professionals to ensure they are appropriate for your specific health situation. Always prioritize open communication with your healthcare team regarding any new supplements or changes to your treatment plan.

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