What to Do If You Miss a Dose of Progesterone for Endometrial Hyperplasia? - Obstetrics and Gynecology

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Forgot to take progesterone?


Hello, Doctor.
I am currently taking progesterone for endometrial hyperplasia and need to take it for three months.
However, I forgot to take it last night and took it 10 hours later in the morning.
Should I continue taking it in the evening or switch to taking it in the morning from now on? What are the potential effects of the delayed dose? Thank you.

Yū, 30~39 year old female. Ask Date: 2024/03/13

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, both are fine and won't have any impact.
Wishing you good health.

Reply Date: 2024/03/13

More Info


If you miss a dose of progesterone while treating endometrial hyperplasia, it’s important to follow specific guidelines to ensure the effectiveness of your treatment and minimize any potential side effects. Here’s a detailed response to your question:
First, if you realize that you’ve missed a dose of progesterone, the general recommendation is to take the missed dose as soon as you remember, provided it’s not too close to the time of your next scheduled dose. In your case, since you took the missed dose 10 hours later, you should continue with your regular dosing schedule from that point. This means if you usually take your medication in the evening, you should continue taking it in the evening, rather than switching to the morning. Consistency in the timing of your medication is crucial for maintaining stable hormone levels in your body.

Delaying a dose of progesterone can potentially affect the treatment’s effectiveness, especially if it happens frequently. Progesterone is used to help regulate the menstrual cycle and manage conditions like endometrial hyperplasia by balancing the effects of estrogen. Missing doses can lead to fluctuations in hormone levels, which may result in irregular bleeding or other side effects. However, taking a single missed dose late is unlikely to cause significant harm, especially if you return to your regular schedule afterward.

It’s also important to monitor your body’s response after missing a dose. If you experience any unusual symptoms, such as increased bleeding, severe abdominal pain, or any other concerning side effects, you should contact your healthcare provider for further guidance. They may need to adjust your treatment plan based on your response.

In terms of the overall treatment for endometrial hyperplasia, progesterone is typically prescribed to counteract the effects of unopposed estrogen, which can lead to abnormal thickening of the endometrial lining. The goal is to induce a regular menstrual cycle and reduce the risk of developing more serious conditions, such as endometrial cancer. Adherence to the prescribed regimen is crucial for achieving these outcomes.

If you find that you frequently forget to take your medication, consider setting reminders on your phone or using a pill organizer to help keep track of your doses. Additionally, if you have any concerns about your treatment or if you experience side effects, it’s always best to discuss these with your healthcare provider. They can provide personalized advice and may suggest alternative treatments or adjustments to your current regimen.

In summary, if you miss a dose of progesterone for endometrial hyperplasia, take it as soon as you remember, continue with your regular schedule, and monitor for any unusual symptoms. Consistency is key in hormone therapy, and maintaining open communication with your healthcare provider will help ensure the best possible outcome for your treatment.

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