Managing VPC and Medication Adjustments for Heart Rhythm Disorders - Cardiology

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Antiarrhythmic medications


I have ventricular premature contractions (VPC) and have undergone stent placement, and I am currently receiving ongoing treatment.
My doctor has prescribed medications including Clopidogrel, Aspirin, Dronedarone, Atorvastatin, Bisoprolol, Diltiazem, Sotalol, and Amiodarone.
However, I am still experiencing discomfort (chest tightness, dizziness, and shortness of breath), and my ECG shows frequent VPCs.
Therefore, this month, my doctor switched Amiodarone to a self-paid medication called Dronedarone (one tablet daily).
I found that Dronedarone is primarily used for atrial fibrillation.
Can Dronedarone be used to treat VPCs? Given that I am taking many medications, are there any interactions between Dronedarone and my other medications? My heart rate occasionally drops below 60, and my diastolic blood pressure sometimes falls below 60.
Is this due to the medications? Is there any danger? I have previously experienced side effects (blurred vision) from long-term use of Amiodarone.
Are there any other more suitable antiarrhythmic medications besides Amiodarone and Dronedarone? Thank you for your guidance, doctor.

JAMES Jiang, 50~59 year old female. Ask Date: 2024/04/05

Dr. He Dongjin reply Cardiology


Hello, you should first clarify whether your discomfort, such as chest tightness, dizziness, and shortness of breath, occurs when there are frequent ventricular premature contractions (VPCs).
If not, there is no need to take Metoprolol; just monitor your symptoms for any worsening.
If it is related to VPCs, then observe whether the medication causes any additional discomfort before considering if this medication is appropriate or if a change in medication is necessary.
A heart rate occasionally below 60 beats per minute and a diastolic blood pressure occasionally below 60 mmHg are acceptable as long as you do not experience any discomfort.
Let's continue to monitor the situation.
Take care from Changhua Hospital.

Reply Date: 2024/04/05

More Info


Managing ventricular premature contractions (VPCs) and the associated medication adjustments can be a complex process, especially for patients with a history of cardiovascular issues such as stent placement. It’s important to address your concerns regarding the use of medications like Prazosin (脈泰克) and their potential interactions, as well as the implications of your current symptoms.

Firstly, VPCs are common and often benign, especially when they occur infrequently. However, they can sometimes be associated with underlying heart conditions, which is why monitoring and appropriate management are crucial. The fact that you have been experiencing symptoms such as chest tightness, dizziness, and shortness of breath warrants careful evaluation. These symptoms could be related to your VPCs, but they may also indicate other cardiovascular issues, especially given your history of stent placement.

Regarding the use of Prazosin, it is primarily indicated for hypertension and symptoms of benign prostatic hyperplasia, but it is not typically used as a first-line treatment for VPCs or other arrhythmias. While it may have some off-label uses, its efficacy in treating VPCs specifically is not well-established. It’s essential to discuss with your cardiologist whether Prazosin is the most appropriate choice for your situation, especially considering your ongoing symptoms and the fact that you are already on multiple medications.

When it comes to potential drug interactions, it is crucial to consider the cumulative effects of the medications you are taking. Each medication can have side effects, and when combined, they may exacerbate certain issues or lead to new ones. For instance, if you are experiencing bradycardia (a heart rate below 60 beats per minute) and low diastolic blood pressure, this could indeed be a result of the medications you are taking, particularly if they have a known side effect of lowering heart rate or blood pressure. It’s advisable to monitor these parameters closely and report any significant changes to your healthcare provider.

In terms of alternative antiarrhythmic medications, there are several options available, but the choice depends on your specific clinical scenario, including the frequency and severity of your VPCs, your overall heart function, and any other underlying conditions you may have. Medications such as beta-blockers (e.g., metoprolol or atenolol) are often used to manage VPCs and can help reduce the frequency of these contractions. However, the decision to switch or add medications should be made collaboratively with your cardiologist, who can assess the risks and benefits based on your individual health status.

Lastly, it’s important to address the anxiety that can accompany the awareness of having VPCs. Many patients find that understanding their condition and having a clear management plan can help alleviate some of the stress associated with these symptoms. Engaging in relaxation techniques, regular physical activity, and maintaining a healthy lifestyle can also contribute positively to your cardiovascular health and overall well-being.

In summary, while Prazosin may not be the ideal treatment for VPCs, it’s essential to have an open dialogue with your healthcare provider about your symptoms, medication regimen, and any potential alternatives. Regular follow-ups and monitoring will help ensure that you are on the right path to managing your heart health effectively.

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