Delayed Period After Stopping Progesterone: What to Expect - Obstetrics and Gynecology

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Discontinuation of Progesterone Therapy


Hello doctor, I previously took progesterone for three months due to endometrial hyperplasia.
I have stopped the medication for about 14 days, but my menstrual period has not arrived yet.
Is this normal, or is there a possibility of pregnancy? Thank you.

Are You, 30~39 year old female. Ask Date: 2024/04/12

Dr. Cao Guotao reply Obstetrics and Gynecology


Your chances of pregnancy seem low.
If you still haven't gotten your period after a week, it is advisable to see a gynecologist.
Wishing you good health.

Reply Date: 2024/04/12

More Info


When it comes to understanding the delayed period after stopping progesterone, particularly in the context of having taken it for three months due to endometrial hyperplasia, there are several factors to consider.
Firstly, it is important to understand how progesterone works in the menstrual cycle. Progesterone is a hormone that plays a crucial role in regulating the menstrual cycle and preparing the body for potential pregnancy. When taken as a medication, it can help to regulate the menstrual cycle, especially in cases of irregular periods or conditions like endometrial hyperplasia, where the lining of the uterus becomes too thick.

After stopping progesterone, it is common for some women to experience a delay in their menstrual period. This delay can occur for various reasons, including hormonal fluctuations as the body readjusts to its natural cycle. In your case, having stopped progesterone about 14 days ago, it is not unusual for your period to be delayed. The body may take some time to resume its normal hormonal rhythm, especially after a prolonged period of hormonal treatment.

Regarding the possibility of pregnancy, it is essential to consider whether you have had unprotected intercourse during the time you were on progesterone and after stopping it. If there is a chance of pregnancy, it would be advisable to take a home pregnancy test or consult with a healthcare provider for a blood test to confirm. Keep in mind that progesterone can sometimes mask the symptoms of early pregnancy, so if you suspect you might be pregnant, testing is crucial.

In terms of what to expect, if your period does not arrive within a few weeks after stopping progesterone, it may be worth consulting with your healthcare provider. They can assess your situation more thoroughly, possibly including a physical examination and additional tests to rule out any underlying issues.
It is also important to note that some women may experience side effects or changes in their menstrual cycle after stopping hormonal treatments. These can include irregular bleeding, changes in cycle length, or even amenorrhea (the absence of menstruation) for a time. If you experience any concerning symptoms, such as severe pain, heavy bleeding, or other unusual changes, seeking medical attention is advisable.

In summary, a delayed period after stopping progesterone is not uncommon and can be a normal part of your body readjusting to its natural hormonal balance. However, if you have concerns about pregnancy or if your period does not return in a reasonable timeframe, it is best to consult with your healthcare provider for personalized advice and management.

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