Managing Low Blood Pressure from Prostate Enlargement Medications - Urology

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Issues with medications for benign prostatic hyperplasia (BPH)


Hello, Doctor: I started taking medication for benign prostatic hyperplasia in July 2023: one capsule of Tamsulosin 0.5 mg in the morning and one tablet of Dutasteride 0.8 mg at bedtime.
Additionally, I began taking the cholesterol medication Lipitor 20 mg once daily in December 2023, which was changed to every other day starting in February 2024.
I have a regular exercise routine, and my blood pressure has not been high; prior to taking medication last year, it was around 100/60, with occasional orthostatic hypotension.
However, in the past two to three weeks, I have experienced increased frequency of low blood pressure (90/50, occasionally 85/45), dizziness, orthostatic hypotension, and fatigue.
Doctor, can long-term use of prostate medication cause low blood pressure? Is it possible for me to adjust or reduce the dosage of my medication? If reduction is not an option, how can I manage the side effects of the medication? Thank you for your response.

Yang Xiansheng, 70~79 year old female. Ask Date: 2024/04/22

Dr. Du Shixi reply Urology


Hello: Ureaflow may slightly lower blood pressure.
If dizziness is confirmed to a significant degree, it is advisable to discuss with your physician whether to change the medication or consider reducing the dosage based on the treatment effect.
Wishing you good health.

Reply Date: 2024/04/22

More Info


Managing low blood pressure, especially in the context of medications for prostate enlargement, is a critical issue that requires careful consideration. The medications you mentioned, such as Tamsulosin (often referred to as "適尿通") and Alfuzosin (referred to as "優列扶"), are alpha-1 adrenergic antagonists. These medications are commonly prescribed to alleviate symptoms of benign prostatic hyperplasia (BPH) by relaxing the muscles in the prostate and bladder neck, which can help improve urine flow. However, one of the known side effects of these medications is orthostatic hypotension, which is a drop in blood pressure that occurs when standing up from a sitting or lying position.

Given your history of low blood pressure (around 100/60 mmHg) and the recent episodes of even lower readings (90/50 mmHg and occasionally 85/45 mmHg), it is plausible that the medications for prostate enlargement are contributing to your symptoms of dizziness, fatigue, and increased frequency of orthostatic hypotension. The combination of these medications can lead to vasodilation, which may exacerbate your existing low blood pressure condition.

In terms of managing your low blood pressure, there are several strategies you can consider:
1. Medication Review: It is essential to discuss with your healthcare provider the possibility of adjusting the dosage of your prostate medications. Sometimes, reducing the dose or switching to a different medication with a lower risk of causing hypotension can be beneficial.

2. Hydration: Ensuring adequate fluid intake can help increase blood volume and potentially alleviate symptoms of low blood pressure. Staying well-hydrated is particularly important if you are experiencing symptoms of dehydration.

3. Dietary Adjustments: Increasing salt intake can help raise blood pressure, but this should be done under the guidance of a healthcare professional, especially if you have other health conditions such as heart disease.

4. Gradual Position Changes: To minimize the risk of orthostatic hypotension, try to change positions slowly. For example, when getting up from a lying or sitting position, do so gradually to allow your body time to adjust.

5. Compression Stockings: Wearing compression stockings can help improve venous return and reduce the pooling of blood in the legs, which may help mitigate symptoms of low blood pressure.

6. Monitoring: Regularly monitor your blood pressure at home to track any changes and report these to your healthcare provider. This information can help guide treatment decisions.

7. Lifestyle Modifications: Continue with your exercise routine, as regular physical activity can improve cardiovascular health and potentially help regulate blood pressure. However, be cautious with high-intensity activities if you are experiencing significant symptoms.

8. Consultation with a Specialist: If your symptoms persist or worsen, it may be beneficial to consult with a cardiologist or a specialist in hypertension who can provide more tailored management strategies.

In conclusion, while medications for prostate enlargement can contribute to low blood pressure, there are various strategies to manage this condition effectively. It is crucial to work closely with your healthcare provider to adjust your treatment plan as needed, ensuring that you maintain a balance between managing your prostate symptoms and avoiding the adverse effects of low blood pressure.

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