Medication Side Effects for Enlarged Prostate Treatment - Urology

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Could you please provide more details regarding the medication issues related to benign prostatic hyperplasia (BPH)?


Hello Dr.
Sun, thank you for taking the time to respond to my questions despite your busy schedule.
I have a history of nasal allergies and hypertension, for which I am taking Amlodipine for blood pressure control and a nasal spray containing Azelastine.
Recently, I noticed that the strength of my urination has decreased compared to before, so I went to the hospital for an ultrasound examination, which revealed benign prostatic hyperplasia (BPH).
My blood test showed a PSA level of 0.450 ng/mL.
The doctor initially prescribed Lafuzon XL prolonged release tablets 10 mg, but I experienced nasal congestion shortly after taking it.
The second medication was changed to Tamsulosin S.R.
Capsules 0.2 mg, but I again experienced nasal congestion along with insomnia, thirst, and dry lips.
Could it be that medications for treating benign prostatic hyperplasia commonly cause nasal congestion as a side effect? If so, does this mean I cannot pursue pharmacological treatment and will have to wait until the condition becomes severe enough to require surgery? I feel worried and helpless!

Kunrao Zhe, 40~49 year old female. Ask Date: 2023/08/30

Dr. Sun Hongshun reply Urology


Hello, concerned individual: Not all prostate medications cause nasal congestion! There are many different types of prostate medications, and you can ask your doctor to gradually adjust the medication to what suits you best (everyone experiences the effects of medication differently).
Wishing you a speedy recovery.

Reply Date: 2023/08/30

More Info


When dealing with medication for enlarged prostate, particularly with drugs like Tamsulosin and Lafuzo, it's important to understand the potential side effects and how they can impact your overall health and quality of life.
Tamsulosin, a common medication for benign prostatic hyperplasia (BPH), works by relaxing the muscles in the prostate and bladder neck, which helps improve urine flow. However, one of the notable side effects of Tamsulosin is nasal congestion or rhinitis. This occurs because the medication can affect the smooth muscle tone in the nasal passages, leading to swelling and blockage. This side effect is relatively common among alpha-blockers, the class of drugs to which Tamsulosin belongs.
In your case, experiencing nasal congestion, insomnia, dry mouth, and dry lips after taking Tamsulosin indicates that your body is reacting to the medication. While these side effects can be bothersome, they are not uncommon. It's essential to communicate these symptoms to your healthcare provider, as they may consider adjusting your dosage or switching you to another medication that may have a different side effect profile.

Regarding your concern about being unable to continue medication due to these side effects, it's crucial to remember that not all patients will experience the same reactions to medications. Some may find that side effects diminish over time as their body adjusts to the medication. Additionally, there are alternative treatments available for BPH, including different medications that may not cause nasal congestion, such as 5-alpha-reductase inhibitors (like finasteride or dutasteride) or other alpha-blockers with a potentially lower incidence of nasal side effects.

If medication continues to be intolerable, surgical options are available for BPH, such as transurethral resection of the prostate (TURP) or laser therapy, which can provide relief from urinary symptoms without the need for ongoing medication. However, these options are typically considered when medication fails to provide adequate relief or if the symptoms significantly impact your quality of life.

In summary, while nasal congestion is a known side effect of medications like Tamsulosin, it does not mean you must forgo treatment altogether. Discuss your symptoms with your healthcare provider, who can help you navigate your options, whether that means adjusting your current treatment plan or exploring alternative therapies. It's essential to address both your urinary symptoms and any side effects to ensure you maintain a good quality of life. Remember, managing BPH is a collaborative process between you and your healthcare team, and there are multiple pathways to find relief.

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