Impact of Medication on Ejaculation Issues in Prostate Enlargement Patients - Urology

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Abnormal ejaculation caused by medication?


I have been suffering from benign prostatic hyperplasia for a long time, with a PSA level between 6 and 7.
Following my doctor's advice, I have been taking dutasteride capsules.
After long-term use, I have gradually experienced side effects related to sexual function.
For my health, I manually induce ejaculation every 5 to 6 days, but since starting the medication, I have been unable to ejaculate normally; most of the time, it results in dry orgasms with little to no semen, occasionally producing one or two drops.
I would like to know if the inability to ejaculate normally over a long period could lead to prostate stones and affect my health.
Thank you.

Kunrao de Xiao Wang, 50~59 year old female. Ask Date: 2022/09/03

Dr. Du Shixi reply Urology


Hello: No, it may be due to the relaxation of the prostate, causing semen to flow into the bladder and being expelled during urination.
Wishing you good health.

Reply Date: 2022/09/03

More Info


The issue of ejaculation problems in patients with prostate enlargement, particularly those taking medications like Doxazosin (多適達), is a significant concern. Doxazosin is an alpha-blocker commonly prescribed to alleviate symptoms of benign prostatic hyperplasia (BPH) by relaxing the muscles in the prostate and bladder neck, which can help improve urine flow. However, one of the known side effects of this medication is its potential impact on sexual function, including ejaculation.

In your case, experiencing "dry orgasms" or minimal semen release can be attributed to the medication's effects on the prostate and seminal vesicles. Doxazosin can interfere with the normal contraction of the muscles involved in ejaculation, leading to retrograde ejaculation, where semen enters the bladder instead of being expelled through the urethra. This condition is generally not harmful but can be distressing for patients who are concerned about their sexual health and fertility.

Regarding your question about the long-term implications of not being able to ejaculate normally, it is important to note that while retrograde ejaculation itself does not typically lead to prostate stones or other serious health issues, it can have psychological effects and impact your quality of life. The prostate does produce fluid that contributes to semen, and while the absence of normal ejaculation may not directly cause prostate stones, it can lead to other complications if the prostate becomes overly full or inflamed.

Chronic retention of prostatic secretions can theoretically contribute to conditions like prostatitis or other forms of prostate discomfort. However, the direct link between dry ejaculation and the formation of prostate stones is not well established in medical literature. It is essential to maintain regular follow-ups with your healthcare provider to monitor your prostate health, especially given your elevated PSA levels, which indicate a need for careful management.

If you are concerned about the side effects of Doxazosin or any other medications you are taking, it is crucial to discuss these concerns with your physician. They may consider adjusting your medication regimen or exploring alternative treatments that may have fewer sexual side effects. Additionally, lifestyle modifications, such as diet and exercise, can also play a role in managing BPH symptoms and overall prostate health.

In summary, while the inability to ejaculate normally can be distressing and may have some implications for prostate health, it is not typically associated with severe complications like prostate stones. Regular monitoring and open communication with your healthcare provider are key to managing your condition effectively. If you experience any new symptoms or significant changes in your health, do not hesitate to seek medical advice.

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