Is Nasal Inflammation After Using Vitreous Gel an Allergic Reaction? - Ophthalmology

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After using Vitis gel, inflammation of the nasal mucosa occurred, but the medication's package insert did not mention this side effect. Is this phenomenon considered an allergic reaction?


I visited a doctor due to dry eye syndrome.
The doctor advised me to use artificial tears every two hours during the day and to apply Vitreous gel before bedtime.
However, a few hours after applying the gel, I wake up due to nasal pain (feeling like my sinuses are inflamed).
I couldn't find any information about this issue in the medication's instructions or on websites, so I'm unsure if this eye ointment is the cause.
Therefore, I'm inquiring about it.
Thank you, doctor.

Lu Yi, 50~59 year old female. Ask Date: 2024/05/07

Dr. Gao Pilin reply Ophthalmology


Hello: Based on your description, the symptoms of nasal pain and sinusitis after using Vitus gel cannot be ruled out as being related to the medication.
Although the product insert does not explicitly mention this side effect, individual responses can vary due to differences in physiology.
However, I have not encountered such a situation before.
I recommend that you discontinue the use of Vitus gel immediately and consult an ophthalmologist and an otolaryngologist for further evaluation of your symptoms and medication usage.

Reply Date: 2024/05/07

More Info


Nasal inflammation after using vitreous gel, particularly in the context of dry eye syndrome, can indeed be concerning. While it is not uncommon for patients to experience various side effects from medications, it is essential to differentiate between an allergic reaction and other potential causes of nasal discomfort.

Firstly, vitreous gel, often used as a lubricant for the eyes, is designed to alleviate symptoms of dryness. However, it is important to note that some individuals may have sensitivities or reactions to the components of these gels. Allergic reactions typically manifest as localized symptoms such as redness, swelling, or itching. If you are experiencing nasal pain or inflammation after using the gel, it may not necessarily be an allergic reaction but could be due to other factors.

One possibility is that the gel could be inadvertently affecting the nasal passages. The eyes and nasal cavity are interconnected through the nasolacrimal duct, which drains tears from the eyes into the nasal cavity. If the gel is applied and excess product drains into the nasal passages, it could potentially irritate the mucosal lining, leading to inflammation or discomfort. This irritation could mimic symptoms of nasal inflammation or sinusitis.

Additionally, if you have pre-existing nasal conditions, such as chronic rhinitis or sinusitis, the use of any topical medication, including vitreous gel, could exacerbate these conditions. The nasal mucosa is sensitive, and any foreign substance can lead to inflammation, especially if there is a history of nasal issues.

It is also worth considering that the timing of your symptoms may coincide with other factors unrelated to the vitreous gel. For example, environmental allergens, changes in weather, or even infections could contribute to nasal inflammation. If you have been exposed to allergens or irritants, this could explain the nasal discomfort you are experiencing.

To address your concerns, it is advisable to consult with your healthcare provider. They can evaluate your symptoms in the context of your overall health and any other medications you may be taking. If necessary, they may recommend alternative treatments for your dry eyes that do not cause nasal discomfort. Additionally, they can assess whether your symptoms are indeed related to the vitreous gel or if there is another underlying cause that needs to be addressed.

In the meantime, consider monitoring your symptoms closely. If you notice a consistent pattern of nasal pain following the use of the vitreous gel, it may be beneficial to discontinue its use temporarily and see if your symptoms improve. Keeping a symptom diary can also help your healthcare provider understand the relationship between the gel and your nasal discomfort.

In summary, while nasal inflammation after using vitreous gel could potentially be related to an allergic reaction, it is more likely due to irritation or exacerbation of pre-existing nasal conditions. Consulting with your healthcare provider will provide clarity and help you find the most appropriate treatment for your dry eyes without causing nasal discomfort.

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