Autonomic Nervous System Dysregulation and Panic Disorder - Psychiatry

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Autonomic nervous system dysfunction


Hello, doctor.
Due to long-term night shifts, I have experienced multiple episodes in the past two months where I suddenly feel palpitations and my heart is pounding strongly, accompanied by a noticeable heartbeat sound.
My blood pressure has soared to 180-190/100-119 during these episodes.
I also experience hyperventilation, which leads to difficulty breathing, shortness of breath, and rapid breathing.
I have undergone X-rays, electrocardiograms, echocardiograms, and exercise stress tests at the hospital, all of which returned normal results.
The last time I had palpitations, elevated blood pressure, and difficulty breathing, I went to the emergency room, where the doctor diagnosed me with panic disorder and prescribed Xanax as needed.
When I am calm, I have no other symptoms, but my blood pressure remains unstable, ranging from 149-159/101-108.
The cardiologist has prescribed antihypertensive medication, but I have tried several different medications without success in lowering my blood pressure; it remains around 140-150 whether I take the medication or not.
Initially, I was on Diovan 160 mg QD, then Concor 1 mg QD, followed by Ceporin 25 mg QD, and now I am on Nebilet 5 mg QD.
I would like to ask the doctor if I should continue taking the antihypertensive medication given this dysregulation.
Is there a possibility of withdrawal symptoms if I stop taking it? Thank you.

A-Hua, 30~39 year old female. Ask Date: 2024/06/05

Dr. Lin Mianzhang reply Psychiatry


Hello Ah-Hua: I apologize for the delayed response as I did not receive a notification for your question.
If your blood pressure remains uncontrolled despite taking antihypertensive medication, you may need to discuss with a cardiologist whether a medication adjustment is necessary or if continuing the medication is warranted.
There are no withdrawal symptoms associated with discontinuing blood pressure medication.
However, if your palpitations are caused by panic disorder, in addition to emergency use of Xanax, you may also need to take an antidepressant to help prevent panic attacks.
I recommend seeking professional help from a mental health specialist.
Wishing you a speedy recovery.

Reply Date: 2024/06/05

More Info


Understanding autonomic nervous system dysregulation and panic disorder is crucial, especially for individuals experiencing symptoms like yours. Your situation, characterized by episodes of palpitations, elevated blood pressure, and hyperventilation, aligns with the manifestations of both autonomic nervous system dysregulation and panic disorder.

The autonomic nervous system (ANS) is divided into two main branches: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS). The SNS is responsible for the "fight or flight" response, which can lead to increased heart rate, elevated blood pressure, and rapid breathing when activated. Conversely, the PNS promotes a "rest and digest" state, helping to calm the body down. In your case, the symptoms you describe—such as heart palpitations and high blood pressure—suggest that your SNS may be overly activated, particularly during stressful situations or when transitioning to sleep.

Panic disorder often involves sudden and intense episodes of fear or discomfort, which can trigger physical symptoms like those you are experiencing. The fact that your medical tests (X-rays, ECG, echocardiograms, and exercise stress tests) returned normal results is reassuring, indicating that there may not be an underlying cardiac issue. However, the persistent nature of your symptoms suggests that they may be linked to anxiety and the dysregulation of your autonomic nervous system.

Regarding your blood pressure medications, it is essential to consult with your healthcare provider before making any changes. The medications you have been prescribed, such as Nebilet (a beta-blocker), are intended to help manage your blood pressure and may also alleviate some of the anxiety-related symptoms. If you stop taking these medications abruptly, you may experience withdrawal symptoms or a rebound increase in blood pressure, which can be dangerous. Therefore, any adjustments to your medication regimen should be done under medical supervision.

In addition to medication, there are several strategies you can consider to help manage your symptoms:
1. Lifestyle Modifications: Since you mentioned working night shifts, it's crucial to establish a consistent sleep schedule and create a calming bedtime routine. This can help regulate your body's internal clock and improve your overall sleep quality.

2. Stress Management Techniques: Incorporating relaxation techniques such as deep breathing exercises, progressive muscle relaxation, or mindfulness meditation can help activate your PNS and reduce anxiety levels. These practices can be particularly beneficial when you feel a panic attack coming on.

3. Physical Activity: Regular exercise can help regulate the autonomic nervous system and improve cardiovascular health. Aim for at least 150 minutes of moderate-intensity aerobic activity each week, along with strength training exercises.

4. Dietary Considerations: A balanced diet rich in fruits, vegetables, whole grains, and lean proteins can support overall health. Additionally, reducing caffeine and alcohol intake may help minimize anxiety and improve sleep quality.

5. Therapy: Cognitive-behavioral therapy (CBT) is an effective treatment for panic disorder. It can help you identify and challenge negative thought patterns and develop coping strategies for managing anxiety.

6. Monitoring: Keep track of your symptoms, including when they occur and any potential triggers. This information can be valuable for your healthcare provider in tailoring your treatment plan.

In summary, your symptoms are likely related to a combination of autonomic nervous system dysregulation and panic disorder. It is essential to continue working with your healthcare provider to manage your blood pressure and anxiety effectively. Implementing lifestyle changes and therapeutic strategies can also play a significant role in alleviating your symptoms and improving your overall well-being. Always consult your doctor before making any changes to your medication or treatment plan.

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