Immunofixation Electrophoresis Issues
A few days ago, I underwent a self-funded immunofixation electrophoresis due to personal reasons, and the results are as follows: total protein 7 g/dL, albumin 62.3% (reference range 54-60, elevated), α-1 2.2% (reference range 1.8-4.0), α-2 6.1% (reference range 7.6-10.9, decreased), beta 12.8% (reference range 11.4-16.1), gamma 16.6% (reference range 13.4-20.7).
Additionally, a suspected β-γ bridge was noted as shown in the following image: https://ibb.co/bbq3JL1.
I would like to know if these electrophoresis abnormalities raise any health concerns and if I should see a doctor for further evaluation.
nan sheng, 30~39 year old female. Ask Date: 2024/07/01
Dr. Gao Jiankai reply Internal Medicine
Hello, thank you for your inquiry.
I believe there is no issue, so please do not worry.
If you are still concerned, you may ask the physician who arranged the examination for a second confirmation.
The Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare, is here to support you.
Reply Date: 2024/07/01
More Info
When interpreting abnormal immunofixation electrophoresis (IFE) results, it is essential to understand the implications of the findings and whether they warrant further medical evaluation. Based on the results you provided, there are several key points to consider.
First, your total protein level is within the normal range, but the distribution of protein fractions shows some abnormalities. The albumin level is slightly elevated, while the alpha-2 globulin fraction is below the reference range. The beta and gamma fractions are within normal limits, but the presence of a suspected beta-gamma bridge is noteworthy. This finding can indicate a potential abnormality in the immune system or plasma cells.
The beta-gamma bridge is often associated with conditions such as monoclonal gammopathy, which can be benign (like Monoclonal Gammopathy of Undetermined Significance, or MGUS) or malignant (such as multiple myeloma). The presence of a bridge suggests that there may be an abnormality in the production of immunoglobulins, which could be indicative of an underlying plasma cell disorder.
Given these findings, it is advisable to consult with a healthcare professional, particularly a hematologist or an immunologist. They can provide a more comprehensive evaluation, which may include additional tests such as serum protein electrophoresis (SPEP), immunofixation electrophoresis (IFE), and possibly a bone marrow biopsy if indicated. These tests can help determine whether there is a significant underlying condition that requires treatment.
Moreover, the presence of abnormal protein levels can also be associated with other conditions, including chronic inflammatory diseases, infections, or liver disease. Therefore, a thorough clinical evaluation, including a detailed medical history and physical examination, is crucial in determining the next steps.
In summary, while your results do not definitively indicate a serious condition, the abnormalities observed, particularly the beta-gamma bridge, warrant further investigation. It is essential to discuss these findings with your doctor, who can guide you on the appropriate follow-up tests and potential referrals to specialists. Early detection and diagnosis are key in managing any potential underlying conditions effectively.
Similar Q&A
Understanding Serum Protein Electrophoresis and Immunoglobulin Results in Plasma Cell Disorders
Hello, doctor. In order to check for any abnormalities in plasma cells, the hospital arranged several blood tests. These include alkaline phosphatase, LDH, IgG, IgM, IgA, calcium, CBC, prothrombin time, APTT, total bilirubin, BUN, creatinine, ALT, serum protein electrophoresis (S...
Dr. Liao Yaopan reply Family Medicine
Hello, regarding your inquiry, it is advisable to discuss the relevant examination results with the specialist physician who arranged the tests for you, as they can provide insights into the relationship with your condition. The examination results are also crucial for determinin...[Read More] Understanding Serum Protein Electrophoresis and Immunoglobulin Results in Plasma Cell Disorders
Understanding Abnormal Blood Test Results: Possible Immune System Disorders
Hello doctor, last month I visited a rheumatology and immunology specialist due to an unexplained rash on my skin (similar to petechiae). Initially, the doctor suspected it might be an allergy, but they still conducted blood tests. The results showed abnormalities as follows: C3 ...
Dr. Gao Jiankai reply Internal Medicine
Hello, thank you for your inquiry. Among the antibodies you tested, some are related to Sjögren's syndrome (Ro/La, C3/C4), some are associated with myositis (Jo-1, Ku), and others are more related to lupus erythematosus (ANA, C3/C4). However, we will consider clinical sympto...[Read More] Understanding Abnormal Blood Test Results: Possible Immune System Disorders
Understanding Abnormal Autoimmune Test Results: Should You Seek a Second Opinion?
Hello, doctor. I previously inquired about my shoulder, neck, and arm pain that has lasted for three months. After examination, the report showed normal indices, except for two abnormal findings: Homogeneous 1/640 (Positive) and Speckled 1/640 (Positive). During my follow-up appo...
Dr. Gao Jiankai reply Internal Medicine
Hello, thank you for your message. The physician's decision may be based on their considerations. If you have concerns, you can prepare your test results and seek a second opinion from another rheumatologist. The Allergy, Immunology, and Rheumatology Department of Changhua H...[Read More] Understanding Abnormal Autoimmune Test Results: Should You Seek a Second Opinion?
Understanding Proteinuria and Glomerular Filtration Concerns in Urology
Hello Dr. Du, please forgive me for continuously asking questions. When one has no one to consult and many doubts, it can be quite overwhelming. I have been troubled by the laboratory test results. The technician mentioned that there is protein leaking from my glomeruli, and that...
Dr. Du Shixi reply Urology
Hello: If possible, find a hospital and a physician for regular follow-ups (preferably a larger hospital with comprehensive specialties). Running around to different places is not very helpful, and carrying your medical records back and forth can be cumbersome. In the future, you...[Read More] Understanding Proteinuria and Glomerular Filtration Concerns in Urology
Related FAQ
Autoimmune Disease
(Internal Medicine)
Test Results(Internal Medicine)
Proteinuria(Internal Medicine)
Lymphadenopathy(Internal Medicine)
Antinuclear Antibody(Internal Medicine)
Rhabdomyolysis(Internal Medicine)
Blood Report(Internal Medicine)
Stds(Internal Medicine)
Sjögren'S Syndrome(Internal Medicine)
Folliculitis(Internal Medicine)