Important Considerations and Side Effects of Long-Term Cotrizine Use - Pharmacology

Dr. Liao Lingmei reply Pharmacology

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Dear Andy,
Here is an explanation regarding the medication you are taking, Cotrizine:
1.
Action: Cotrizine is a brand name for a medication containing Ketoconazole, with each tablet containing 200 mg.
This medication is typically used to treat conditions caused by fungal infections affecting the skin, throat, urethra, and lungs.
It is classified pharmacologically as an antifungal agent.
2.
Dosage and Administration: The dosage and administration should follow your physician's prescription.
The method of using antifungal agents can vary depending on the type of antifungal, whether intermittent therapy is used, and the severity of the affected area, which can influence the duration of treatment.
Generally, unless intermittent therapy is employed, continuous use like yours typically requires a treatment period of at least two weeks.
In some cases, conditions like onychomycosis (fungal nail infection) may require treatment for up to six months to fully resolve.
The decision to discontinue treatment should be based on your physician's assessment of your condition.
Even if symptoms of infection disappear during treatment, do not stop taking the medication without consulting your doctor; it is essential to complete the entire course of treatment to achieve a cure and prevent recurrence.
The medication can be taken on an empty stomach or with food.
3.
Precautions:
i.
Before taking this medication, please inform your physician if you have any of the following: pregnancy or breastfeeding (you may skip this point), a history of drug allergies, other medical conditions (such as liver or kidney disease, arrhythmias, or insufficient gastric acid secretion), or if you are taking other medications (such as antihistamines, antacids, anticoagulants, or even over-the-counter medications).
Your doctor will determine whether the medication should be used.
If you have ever had or currently have liver disease, regular monitoring of liver function tests is advised.
ii.
Avoid consuming alcoholic beverages while taking this medication, and wait at least one day after stopping the medication before drinking alcohol.
Additionally, if you are taking antacids or medications that suppress gastric acid secretion, these should be taken at least two hours apart from this medication.
iii.
If you forget to take a dose: take it as soon as you remember.
However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
Do not take two doses at once.
4.
Side Effects and Management:
i.
If you experience a rash, itching, or symptoms due to liver abnormalities (such as unusual fatigue, nausea, vomiting, jaundice [yellowing of the skin or eyes], dark urine, or pale stools), stop taking the medication and seek medical attention immediately.
ii.
For constipation, diarrhea, headache, or dizziness: if symptoms persist or are severe, please inform your physician.
iii.
Men may experience breast enlargement and tenderness, and blood pressure may increase (especially at higher doses).
Monitor your blood pressure and inform your physician of any changes.
5.
Storage: Store this medication in a cool, dry place out of reach of children, and avoid direct sunlight.
Do not leave it in a hot car.
It does not need to be refrigerated.
Ensure you see your doctor or refill your prescription before running out of medication.
When going out, confirm that you have enough medication with you, and keep it in your carry-on luggage, as checked luggage may be lost or exposed to extreme temperatures that could affect the stability of the medication.
I hope this information meets your needs.
If you have any further questions or require more details, please feel free to ask.
Wishing you health and happiness!

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Reply Date: 2004/04/05