Is It Safe to Add Probiotics and Enzymes to Infant Formula? - Pediatrics

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Hello Dr.
Huang: My daughter is now over three months old.
Recently, she has had a poor appetite and does not like to drink milk.
I was planning to change her formula, but a pharmacist at a chain pharmacy suggested adding Bifidobacterium, enzymes, and NutriBaby granules to her formula.
He said this could increase the beneficial bacteria in her gastrointestinal tract and improve her appetite.
Can I add these substances to my daughter's formula at her age? If I do, are there any potential side effects? I have heard that introducing substances too early can harm a child's kidneys; is this true?

Guo Tai Tai, 20~29 year old female. Ask Date: 2000/12/25

Dr. Huang Zheming reply Pediatrics


Dear Mrs.
Kuo,
Your love and care for your children are truly admirable.
Regarding the addition of Bifidobacterium, it is generally considered a natural probiotic.
Infants who are breastfed not only receive more antibodies but also natural probiotics, which can enhance their immune system and gastrointestinal absorption.
However, after the age of one, the presence of these beneficial bacteria tends to decrease.
For infants who are formula-fed, the addition of Bifidobacterium can aid digestion, promote nutrient absorption, and help maintain a balanced nutritional ecosystem within the body.
Therefore, for your adorable baby who is just over three months old, introducing Bifidobacterium at this stage should not be too early, and there are currently no reports indicating any harm to kidney function from this natural probiotic.
Wishing your baby health and beauty!

Reply Date: 2000/12/25

More Info


When it comes to the safety of adding probiotics and enzymes to infant formula, especially for a three-month-old baby, there are several important considerations to keep in mind.
Firstly, probiotics are live microorganisms that can provide health benefits, particularly for gut health. They are often used to help balance the gut microbiome, which can be beneficial for digestion and may help with issues like colic or constipation. However, the introduction of probiotics in infants should be approached with caution. The American Academy of Pediatrics (AAP) suggests that while some probiotics are generally considered safe for infants, the specific strains and dosages should be carefully evaluated. Not all probiotics are created equal, and some may not be appropriate for very young infants.

Enzymes, on the other hand, are proteins that help catalyze biochemical reactions, including those involved in digestion. While enzyme supplements can be helpful for certain digestive disorders in older children and adults, their use in infants is less well-studied. The introduction of digestive enzymes in infants should be done under the guidance of a healthcare professional, as their digestive systems are still developing.

Regarding the specific concerns about kidney health, it is true that introducing certain substances too early can put stress on an infant's immature kidneys. Infants have a limited ability to process and excrete substances, and their kidneys are still developing. Therefore, adding supplements like probiotics and enzymes without medical supervision could potentially lead to complications, especially if the infant has underlying health issues or if the dosages are not appropriate for their age and weight.

In your case, since your baby is only three months old and is experiencing a lack of appetite, it is crucial to consult with a pediatrician before making any changes to her diet or adding supplements. The pediatrician can assess her overall health, growth, and nutritional needs, and provide tailored advice. They may suggest alternative strategies to improve her appetite, such as ensuring she is feeding at the right times, checking for any underlying health issues, or considering a different formula that may be more palatable for her.

In summary, while probiotics and enzymes can offer benefits, their use in infants, particularly those as young as three months, should be approached with caution and under medical guidance. It is essential to prioritize the infant's safety and well-being by consulting with a healthcare professional before introducing any new supplements.

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