Chronic Hepatitis: Symptoms, Risks, and Dietary Management - Gastroenterology and Hepatology

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Chronic hepatitis


The hospital liver function tests show ALT 56, AST 48, and GPT 91, with HBsAg and Anti-HCV both normal.
Does this indicate chronic hepatitis? Is there a possibility that this could be a precursor to liver cancer? Can chronic hepatitis be cured? I've heard that chronic hepatitis can progress to cirrhosis and then to liver cancer.
Is this true? How should one manage diet and lifestyle with chronic hepatitis? What is fatty liver? Thank you for your response, doctor.

Danxin de ren, 20~29 year old female. Ask Date: 2004/04/21

Dr. Liang Jiade reply Gastroenterology and Hepatology


Hello, AST = GOT and ALT = GPT.
There are many reasons for elevated liver function indices, including viral and bacterial infections, medication use, obesity, and lack of sleep, among others.
However, a temporary increase does not necessarily indicate chronic hepatitis, nor can it be directly linked to liver cancer.
Of course, the treatment methods will depend on the underlying cause.
Typically, chronic persistent hepatitis (especially viral infections) can lead to cirrhosis after several decades, increasing the risk of developing liver cancer.
Fatty liver is characterized by excessive fat accumulation in the liver, which can cause the liver to appear particularly bright on ultrasound.
If the condition is severe, it may still lead to abnormal liver function.
The causes are related to diet, lack of exercise, and elevated blood lipids, among other factors.

Reply Date: 2004/04/21

More Info


Chronic hepatitis is a significant health concern that can lead to severe complications, including liver cirrhosis and liver cancer. Based on your lab results showing elevated ALT (alanine aminotransferase), GOT (aspartate aminotransferase), and GPT (glutamate pyruvate transaminase), it suggests that there is some level of liver inflammation or damage. However, the normal HBsAg (Hepatitis B surface antigen) and Anti-HCV (antibody to Hepatitis C virus) indicate that you do not have active Hepatitis B or C infections, which are common causes of chronic hepatitis.

To address your concerns:
1. Is this chronic hepatitis?
Your elevated liver enzymes indicate liver inflammation, but without further testing, it is not definitive that you have chronic hepatitis. Chronic hepatitis is typically diagnosed when liver inflammation persists for six months or longer. It is essential to consult a healthcare provider for a comprehensive evaluation, including a detailed medical history, physical examination, and possibly imaging studies or a liver biopsy.

2. Is there a possibility of liver cancer?
While chronic hepatitis can increase the risk of developing liver cancer, particularly if it progresses to cirrhosis, your current lab results do not directly indicate liver cancer. However, chronic liver disease can indeed lead to cirrhosis, which is a significant risk factor for hepatocellular carcinoma (the most common type of liver cancer). Regular monitoring and follow-up with your healthcare provider are crucial to assess your liver health over time.

3. Can chronic hepatitis be cured?
The possibility of curing chronic hepatitis depends on the underlying cause. For instance, chronic viral hepatitis (like Hepatitis B and C) can be treated effectively with antiviral medications, leading to viral suppression and potential resolution of liver inflammation. Non-viral causes, such as autoimmune hepatitis or alcoholic liver disease, may require different management strategies. Lifestyle changes, such as abstaining from alcohol and maintaining a healthy weight, can also significantly improve liver health.

4. Dietary management for chronic hepatitis:
If you have chronic hepatitis, dietary management is essential. Here are some general guidelines:
- Balanced Diet: Focus on a well-balanced diet rich in fruits, vegetables, whole grains, and lean proteins. This helps support liver function and overall health.

- Limit Alcohol: Alcohol can exacerbate liver damage, so it is advisable to avoid it entirely.

- Healthy Fats: Incorporate healthy fats, such as those found in avocados, nuts, and olive oil, while avoiding trans fats and excessive saturated fats.

- Hydration: Stay well-hydrated, as this supports liver function.

- Avoid Processed Foods: Minimize intake of processed foods high in sugar, salt, and unhealthy fats, as they can contribute to liver stress.

- Regular Meals: Eating regular, smaller meals can help maintain energy levels and support liver function.

5. What is fatty liver?
Fatty liver disease, or hepatic steatosis, occurs when excess fat builds up in the liver. It can be caused by various factors, including obesity, diabetes, high cholesterol, and excessive alcohol consumption. Fatty liver can be benign, but it can progress to non-alcoholic steatohepatitis (NASH), which can lead to cirrhosis and liver cancer. Lifestyle modifications, such as weight loss, regular exercise, and a healthy diet, are crucial in managing fatty liver disease.

In summary, while your elevated liver enzymes warrant further investigation, they do not definitively indicate chronic hepatitis or liver cancer. Regular follow-up with your healthcare provider, along with lifestyle and dietary modifications, can help manage your liver health effectively. Always consult with a healthcare professional for personalized advice and treatment options.

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