Managing Eczema in Infants: Safety of Elidel and Steroid Alternatives - Dermatology

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Atopic dermatitis


Hello Dr.
Zheng: My child developed atopic dermatitis two weeks after birth and is now 10 months old.
We are using breast milk and hypoallergenic formula, but the condition still flares up.
We also use emollients and bathing products specifically for atopic dermatitis, yet it continues to recur.
The doctor has been prescribing topical corticosteroids long-term, but due to concerns about side effects, we have switched to ELIDEL (Pimecrolimus), which has shown good results.
I would like to know if there are any side effects for such a young child.
Although the product trials claim there are no side effects, I would appreciate your expert opinion.
Thank you.

MAY, 30~39 year old female. Ask Date: 2004/05/02

Dr. Zheng Lizhen reply Dermatology


Hello: Currently, there have been no reports of adverse side effects.
This is a response from Dr.
Cheng Li-Chen, Department of Dermatology, Taoyuan Hospital, Ministry of Health and Welfare.

Reply Date: 2004/05/02

More Info


Managing eczema in infants, particularly at such a young age, can be quite challenging for parents. Eczema, or atopic dermatitis, is a common skin condition that often begins in infancy and can lead to significant discomfort for the child. The use of topical treatments, such as Elidel (pimecrolimus), and the long-term reliance on steroid creams can raise concerns about safety and side effects.

Elidel is a non-steroidal topical medication that is often prescribed for the treatment of eczema in children aged two years and older. It works by inhibiting the immune response that leads to inflammation, thereby reducing the symptoms of eczema. One of the primary advantages of Elidel is that it does not carry the same risks associated with long-term steroid use, such as skin thinning, stretch marks, and potential systemic absorption leading to more serious side effects.

While clinical trials and studies have indicated that Elidel is generally well-tolerated, it is essential to recognize that every child is different. Some potential side effects of Elidel may include local skin reactions such as burning, stinging, or itching at the application site. These reactions are usually mild and transient. However, there is a theoretical risk of increased susceptibility to infections, as the medication modulates the immune response. Therefore, it is crucial to monitor the child for any signs of infection or worsening of the eczema.

In your case, since your child is only ten months old, it is understandable to have concerns about the safety of using Elidel. While the medication is approved for use in children over two years old, some dermatologists may prescribe it off-label for younger infants if they believe the benefits outweigh the risks. It is essential to have an open dialogue with your pediatric dermatologist about your concerns and to ensure that your child is closely monitored while using this medication.

In addition to Elidel, there are other non-steroidal alternatives and supportive measures that can help manage eczema in infants. These include:
1. Moisturizers: Regular application of emollients or moisturizers is crucial in managing eczema. These products help to maintain skin hydration and create a barrier to prevent irritants from penetrating the skin.

2. Wet Wrap Therapy: This involves applying a moisturizer and then covering the affected areas with wet bandages. This method can help to hydrate the skin and reduce inflammation.

3. Antihistamines: While not a direct treatment for eczema, antihistamines can help alleviate itching, especially at night, which can improve sleep for both the child and the parents.

4. Avoiding Triggers: Identifying and avoiding potential triggers, such as certain fabrics, soaps, or foods, can help reduce flare-ups. Keeping the environment cool and humid can also be beneficial.

5. Phototherapy: In some cases, controlled exposure to ultraviolet light may be recommended for more severe eczema that does not respond to topical treatments.

6. Dietary Considerations: If food allergies are suspected, working with a pediatric allergist to identify and manage these allergies can be an essential part of eczema management.

In conclusion, while Elidel can be an effective treatment for eczema in infants, it is essential to weigh the benefits against potential risks. Regular follow-up with a healthcare provider is crucial to monitor the child's response to treatment and make any necessary adjustments. Always consult with your pediatric dermatologist before making any changes to your child's treatment plan, and consider incorporating a comprehensive approach that includes moisturization, avoidance of triggers, and other supportive measures to manage eczema effectively.

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