Managing Theophylline Side Effects: When to Adjust Your Dosage - Pulmonology

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125 mg Theophylline


Hello Dr.
Jian: Due to prolonged recurrent colds, I developed bronchitis.
After taking the bronchodilator prescribed by my doctor, I experienced nausea, dizziness, and palpitations.
Given these adverse reactions, can I continue taking the medication, or should I reduce the dosage? Currently, I am taking it twice a day (after breakfast and dinner).
Other medications include MUCORA, FINSKA-LP, and BROWN MIXTURE.
Thank you for your assistance!

Xiao Xin, 30~39 year old female. Ask Date: 2004/05/05

Dr. Jian Linzhen reply Pulmonology


THEOPHYLLINE has only a mild bronchodilator effect and has a narrow safety margin.
The most common cardiac side effects are sinus tachycardia and ventricular ectopy.
Elevated blood levels can lead to nausea, vomiting, tremors, tachycardia, and seizures.
Additionally, even at normal blood concentrations, these side effects may occur, particularly gastrointestinal discomfort, nausea, and vomiting, which are due to individual susceptibility and are not related to the dosage.

Reply Date: 2004/05/05

More Info


Theophylline is a medication commonly used as a bronchodilator to treat respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). It works by relaxing the muscles in the airways and increasing airflow to the lungs. However, like many medications, theophylline can cause side effects, and it is crucial to manage these appropriately to ensure patient safety and comfort.

In your case, experiencing nausea, dizziness, and palpitations after taking theophylline suggests that you may be experiencing side effects that could be related to the dosage or your individual sensitivity to the medication. Theophylline has a narrow therapeutic index, meaning that the difference between an effective dose and a toxic dose is small. Therefore, it is essential to monitor for side effects closely.

When considering whether to continue taking theophylline or to adjust the dosage, several factors should be taken into account:
1. Severity of Side Effects: If the side effects are mild and manageable, it may be possible to continue the medication with close monitoring. However, if the side effects are severe or worsening, it may be necessary to reduce the dosage or discontinue the medication altogether.

2. Therapeutic Levels: Theophylline levels in the blood can be monitored through a simple blood test. If your levels are above the therapeutic range, this could explain the side effects you are experiencing. In such cases, adjusting the dosage may be necessary.

3. Other Medications: You mentioned taking other medications, including MUCORA, FINSKA-LP, and BROWN MIXTURE. It is essential to consider potential drug interactions, as these could exacerbate the side effects of theophylline. Always inform your healthcare provider about all medications you are taking.

4. Underlying Conditions: If you have any underlying health conditions, such as heart problems or liver disease, these could affect how your body metabolizes theophylline and may necessitate a dosage adjustment.

5. Consulting Your Healthcare Provider: It is crucial to discuss your symptoms with your healthcare provider. They can assess your situation more thoroughly and determine whether you should continue taking theophylline, adjust the dosage, or consider alternative treatments.

In summary, if you are experiencing significant side effects from theophylline, it is advisable to consult your healthcare provider before making any changes to your medication regimen. They can help determine the best course of action based on your specific circumstances, including the possibility of adjusting the dosage or exploring alternative therapies. Remember, managing medications effectively is a collaborative process between you and your healthcare team, and open communication is key to achieving the best outcomes.

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