the Differences Between Home and Clinical Glycolic Acid Use - Dermatology

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Alpha hydroxy acid (AHA)


What is the difference between low-concentration alpha hydroxy acids (e.g., glycolic acid 10%) typically used at home and high-concentration alpha hydroxy acids used in clinical settings? Which one has more significant effects? Are there any side effects associated with long-term use of alpha hydroxy acids? Thank you!

nick, 20~29 year old female. Ask Date: 2000/11/16

Dr. Zheng Lizhen reply Dermatology


The difference between low concentration and high concentration is, of course, the concentration itself! The concentration of alpha hydroxy acids (AHAs) used in hospitals typically ranges from 20% to 70%, and there are also combination AHAs.
High-concentration AHAs can achieve therapeutic effects quickly, with treatments performed approximately every 3 to 4 weeks.
During this interval, home-use AHA products can be utilized to maintain the results, gradually extending the time between treatments.
Long-term use has not shown any significant side effects, as long as the dosage and concentration are monitored.

Reply Date: 2000/11/16

More Info


Glycolic acid, a type of alpha hydroxy acid (AHA), is widely used in both home skincare products and professional treatments in clinical settings. Understanding the differences between these two applications is crucial for anyone considering incorporating glycolic acid into their skincare routine.


Concentration and Formulation
The primary difference between home-use glycolic acid products and those used in clinical settings is the concentration. Over-the-counter (OTC) glycolic acid products typically contain lower concentrations, often around 5-10%. These lower concentrations are designed to be safe for daily use and to minimize the risk of irritation, making them suitable for a wide range of skin types, including sensitive skin.

In contrast, clinical glycolic acid treatments can contain much higher concentrations, often ranging from 20% to 70%. These higher concentrations are used in professional settings to achieve more significant results in a shorter amount of time. Clinical treatments are usually performed by licensed dermatologists or estheticians who can monitor the skin's response and adjust the treatment accordingly.


Efficacy
When it comes to efficacy, higher concentrations of glycolic acid used in clinical settings tend to produce more noticeable results, such as improved skin texture, reduced fine lines, and enhanced radiance. These treatments can also effectively address specific skin concerns like acne, hyperpigmentation, and sun damage. However, the results from home-use products can still be beneficial, especially with consistent use over time. They can help maintain skin health, promote exfoliation, and improve overall skin appearance, albeit at a slower pace.


Side Effects and Safety
Both home and clinical glycolic acid applications can lead to side effects, but the risk is generally higher with clinical treatments due to the concentration and potential for deeper penetration into the skin. Common side effects include:
- Irritation: Redness, stinging, or burning sensations can occur, especially with higher concentrations.

- Peeling: Exfoliation is a desired effect, but excessive peeling can lead to discomfort and potential skin damage.

- Sensitivity: Increased sensitivity to sunlight is common after glycolic acid use, necessitating the application of sunscreen.

For home-use products, the lower concentrations typically result in milder side effects. However, users should still be cautious, especially if they have sensitive skin or are using other active ingredients (like retinoids or other AHAs/BHAs) in their skincare routine.


Recommendations
For individuals considering glycolic acid, it is essential to start with lower concentrations to gauge skin tolerance. Gradually increasing the concentration or frequency of use can help minimize irritation. Consulting with a dermatologist before starting any glycolic acid regimen, especially if considering clinical treatments, is advisable. They can provide personalized recommendations based on skin type, concerns, and overall skin health.

In summary, while both home and clinical glycolic acid products serve the purpose of exfoliation and skin improvement, their differences in concentration, efficacy, and potential side effects are significant. Understanding these factors can help individuals make informed decisions about their skincare routines and achieve the best possible results while minimizing risks.

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