Can You Get Pregnant While Taking Liver Protection Medication?

Is it safe to become pregnant while taking Liver An?

Hello, I have known since elementary school that I am a carrier of hepatitis B.
In November of last year, I was tested and found to have elevated liver enzymes, approximately three times above the normal range.
After testing negative for the e antigen, my doctor prescribed liver protective agents for me to take over the past six months, during which I have had blood tests every two months.
However, my liver enzyme levels have not decreased but have instead increased, and by the end of June, my liver enzymes rose to over 200, about eight times the normal value, and the e antigen has turned positive.
My doctor confirmed that I do not have hepatitis C and has recommended that I start treatment with antiviral medication.
The doctor mentioned that once I start taking the antiviral medication, I need to continue for one to one and a half years, and there is a 50% chance of relapse after treatment, as well as the possibility of viral mutations.
My questions are as follows:
1.
Despite consistently taking the liver protective agents, maintaining a normal lifestyle with at least six hours of sleep, and avoiding smoking and alcohol, why have my liver enzyme levels increased instead of decreased? Could the liver protective agents be the reason for the rise in enzyme levels?
2.
I am planning to conceive.
If I become pregnant while taking the antiviral medication, will it affect the fetus? If there is an impact, how long after completing the antiviral treatment should I wait before trying to conceive?
3.
If I experience viral mutations while on the antiviral medication, are there treatment options available?

Xiao Mi, 30~39 year old female. Ask Date: 2004/06/28

Dr. Liang Jiade reply Gastroenterology and Hepatology

Hello, in response to your question, here is a brief summary: 1.
Hepatoprotective agents consist of essential nutrients produced by the liver itself, but they do not have therapeutic effects against viral hepatitis and will not cause liver function abnormalities.
2.
It is advised not to become pregnant while taking Hepa-Merz.
There is no specific timeframe for when one can conceive after using Hepa-Merz, but it is recommended to wait at least a few weeks (until the drug levels have decreased to negligible amounts).
3.
There are currently several antiviral medications available for mutated strains of the virus, but domestically, only one drug, Adefovir, has been approved by the health authorities.
Clinical experience over 1-2 years indicates that the likelihood of developing resistant strains is only 2-5%.

Reply Date: 2004/06/28

More Info

When considering pregnancy while taking liver protection medication, particularly in the context of chronic hepatitis B and elevated liver enzymes, there are several important factors to consider.
1. Understanding Liver Protection Medications: Liver protection medications, such as those you have been prescribed, are typically aimed at supporting liver function and may not directly treat the underlying viral infection. It's crucial to understand that these medications can sometimes have varying effects on liver enzyme levels. The rise in your liver enzymes, despite adherence to medication and a healthy lifestyle, may not necessarily be due to the medications themselves. Factors such as the progression of the disease, the body's response to the virus, or even the potential for other underlying conditions could contribute to this situation. Regular monitoring and open communication with your healthcare provider are essential to determine the best course of action.

2. Pregnancy Considerations While on Medication: Regarding your plans for pregnancy, it is generally advised to avoid conception while on antiviral medications like "Gan An Neng" (or similar antiviral treatments). The potential risks to the fetus are not fully understood, and while some studies suggest that certain antiviral medications may not cause significant harm, the lack of controlled studies in pregnant women means that caution is warranted. It is advisable to discuss with your healthcare provider the specific risks associated with the medication you are taking. If you do conceive while on these medications, your healthcare provider will likely monitor your pregnancy closely and may adjust your treatment plan accordingly.

3. Timing for Conception After Treatment: If you are considering stopping the medication to conceive, it is essential to consult your healthcare provider about how long you should wait after completing treatment before trying to conceive. While there is no universally established timeframe, many healthcare professionals recommend waiting at least a few weeks to ensure that the medication is cleared from your system and to minimize any potential risks to the developing fetus.

4. Managing Viral Mutations: If there is a concern about viral mutations due to the treatment, it is important to discuss this with your healthcare provider. There are alternative antiviral therapies available if resistance develops, and your doctor can guide you on the best treatment options based on your specific situation. Regular follow-ups and blood tests will help monitor your liver function and viral load, allowing for timely adjustments to your treatment plan.

In summary, while it is possible to conceive while on liver protection medication, it is crucial to have a thorough discussion with your healthcare provider about the potential risks and the best timing for pregnancy. Your liver health and the health of your future child are paramount, and a tailored approach to your treatment and family planning will help ensure the best outcomes. Always prioritize open communication with your healthcare team to navigate these complex decisions effectively.

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