CA125 Levels: Could Uterine Fibroids Be the Cause? - Family Medicine

More Info

---

CA-125 is a protein that is often elevated in various conditions, particularly those related to the female reproductive system. A CA-125 level of 46 is indeed considered elevated, as the normal reference range is typically less than 35 U/mL. While elevated CA-125 levels can be associated with ovarian cancer, they can also be influenced by a variety of benign conditions, including uterine fibroids, endometriosis, pelvic inflammatory disease, and even menstruation.

In your case, the discovery of a 2.8 cm uterine fibroid could potentially explain the elevated CA-125 level. Uterine fibroids, also known as leiomyomas, are non-cancerous growths of the uterus that can cause various symptoms, including heavy menstrual bleeding, pelvic pain, and pressure symptoms. They can also lead to an increase in CA-125 levels, although the exact mechanism is not entirely understood. The presence of fibroids can cause inflammation or irritation in the pelvic region, which may contribute to the elevation of CA-125.

It is important to note that while a high CA-125 level can raise concerns about malignancy, it is not a definitive marker for cancer. Many women with benign conditions can have elevated CA-125 levels. For instance, conditions such as endometriosis and pelvic inflammatory disease are known to cause increases in CA-125. Additionally, factors such as menstruation, pregnancy, and even certain gastrointestinal conditions can influence CA-125 levels.

Given your situation, it is advisable to follow up with your healthcare provider for further evaluation. They may recommend additional imaging studies, such as a pelvic ultrasound or MRI, to assess the fibroid and rule out any other potential causes for the elevated CA-125. If there are no concerning features on imaging and if the fibroid is not causing significant symptoms, your doctor may suggest a watchful waiting approach, especially if you are considering pregnancy.

If you experience worsening symptoms or if there are changes in your CA-125 levels, further investigation may be warranted. In some cases, a referral to a specialist, such as a gynecologic oncologist, may be appropriate for further evaluation and management.

In summary, while your elevated CA-125 level could be related to the presence of uterine fibroids, it is essential to consider the broader context of your health and any accompanying symptoms. Regular monitoring and open communication with your healthcare provider will be key in managing your situation effectively.