Liver Transplant Risks and Options for Patients - Surgery

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Confusion about liver transplantation?


I would like to consult a physician regarding my mother, who is suffering from cirrhosis and liver cancer.
Since I am living abroad, I am unable to fully understand her condition.
Among my five siblings, only I share the same blood type as my mother.
My sister mentioned that if necessary, I might have to undergo a liver resection to save her.
However, when I discussed this with my husband, he suggested that we should consider going to mainland China for a liver transplant, and he is willing to spend money on it, but he does not want to take any risks.

Could you please explain the risks and potential complications for a liver donor? Additionally, what are your thoughts on getting a liver transplant in mainland China? If my mother were to undergo a liver transplant, what risks would she face? Is a liver transplant a good option?
Furthermore, if she is currently receiving a combination of Western and traditional Chinese medicine for her cirrhosis, is there a possibility for improvement in her symptoms? The physician mentioned that cirrhosis is more critical than liver cancer.
What should I do in this situation? I would greatly appreciate your insights.

Qingcai, 40~49 year old female. Ask Date: 2004/10/26

Dr. He Zhenming reply Surgery


Hello: Most liver cancer cases are caused by cirrhosis.
In Taiwan, 80% of liver cancer cases are due to hepatitis B and C leading to the progression of cirrhosis into liver cancer.
Currently, cirrhosis cannot be improved.
If liver cancer develops after cirrhosis, the prognosis after liver transplantation is not very favorable, and age can also affect the postoperative outcomes for patients.
If treatment is not possible, liver transplantation is the only option.

Reply Date: 2004/10/26

More Info


Liver transplantation is a complex and critical procedure, especially for patients with liver cirrhosis and liver cancer. Understanding the risks and options available for both the recipient and the donor is essential for making informed decisions.


Risks and Considerations for Living Liver Donation
1. Surgical Risks: As with any major surgery, living liver donation carries risks such as bleeding, infection, and complications from anesthesia. The donor will undergo a major surgical procedure that involves removing a portion of their liver, which can lead to significant postoperative pain and a longer recovery time.

2. Long-term Health Effects: While most living donors recover well and can lead normal lives post-surgery, there are potential long-term effects. Some donors may experience changes in liver function, and there is a small risk of developing liver-related complications later in life. Studies suggest that living donors generally have good outcomes, but they should be monitored regularly for any potential issues.

3. Psychological Impact: The emotional and psychological aspects of being a living donor can also be significant. Donors may experience anxiety about the surgery, concerns about their own health post-donation, and emotional stress related to the recipient's condition.


Risks and Considerations for Liver Transplantation
1. Recipient Risks: For the recipient, liver transplantation is a life-saving procedure, but it is not without risks. There is a chance of complications such as rejection of the new liver, infections, and complications related to immunosuppressive medications that are necessary to prevent rejection. The risk of complications can be higher in patients with pre-existing conditions like liver cancer.

2. Cancer Recurrence: In patients with liver cancer, there is a risk that the cancer may recur after transplantation. The selection criteria for liver transplantation in cancer patients are strict, and careful evaluation is necessary to determine if the patient is a suitable candidate.

3. Post-Transplant Care: After transplantation, patients require lifelong follow-up care, including regular blood tests and monitoring for liver function and potential complications. Adherence to medication regimens is crucial for the success of the transplant.


Options for Treatment
1. Living Donation vs. Deceased Donation: If you are considering living donation, it is essential to discuss this with a transplant center. They will evaluate both the donor and the recipient to ensure that the procedure is safe and appropriate. If living donation is not an option, deceased donor transplantation may be considered, but this depends on availability and the urgency of the recipient's condition.

2. Alternative Treatments: While liver transplantation is often the best option for end-stage liver disease, there are other treatments available for liver cirrhosis and liver cancer. These may include medications, lifestyle changes, and in some cases, palliative care to manage symptoms and improve quality of life.

3. Integrative Approaches: Some patients explore integrative approaches that combine conventional medicine with complementary therapies. While these may help manage symptoms, it is crucial to discuss any alternative treatments with a healthcare provider to ensure they do not interfere with standard medical care.


Conclusion
In summary, the decision to proceed with liver donation or transplantation involves weighing the risks and benefits for both the donor and the recipient. It is essential to have thorough discussions with healthcare professionals specializing in liver disease and transplantation. They can provide personalized advice based on your mother's specific medical condition and help you navigate the complexities of this process. Additionally, considering the emotional and psychological aspects of both donation and transplantation is crucial for all parties involved.

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