Pediatric Purpura
Hello Dr.
Zhou, my child is currently four months old.
When he was a little over one month, he suddenly developed petechiae one night, which increased throughout the night.
The next day, we immediately went to the hospital, and a blood test showed a platelet count of only 8,000.
He was admitted to the hospital, and by that afternoon, his platelet count had dropped to 3,000.
He was started on steroids and received steroid injections, and the next day he was given a dose of intravenous immunoglobulin.
After that, his platelet count returned to normal, but the steroids need to be tapered off, and he has been off medication for two weeks now.
I would like to ask: 1.
My child did not have a cold; why did he develop thrombocytopenic purpura? Is it allergic purpura? Now that he has recovered, is there a chance of relapse? 2.
He has not received any vaccinations since he was two months old; when can he start getting vaccinated? 3.
What are the normal values for WBC, RBC, HGB, and PLT for a four-month-old baby? 4.
What should we pay attention to at this time?
Wawa, 30~39 year old female. Ask Date: 2000/11/16
Dr. Zhou Zuyou reply Pediatrics
Response: (1) Purpura can be classified as either extrinsic or intrinsic.
Certain viral infections that suppress bone marrow production lead to extrinsic purpura, which typically does not recur.
Allergic purpura is classified as intrinsic and may recur when exposed to specific triggers.
It is difficult to determine if your child has allergic purpura.
(2) It is recommended to consult Dr.
Huang Li-Min at National Taiwan University Hospital, as he is a specialist in this field.
(3) The normal values for a 4-month-old child are as follows: WBC: 6,000-12,000, RBC: 3.1 million-5 million, HGB: 9.0-14 g/dL, and PLT: 150,000-400,000.
(4) Please provide more detailed information about your child and consult with a pediatric hematologist, Dr.
Hung Shao-Hui, the head of pediatrics at Tainan Hospital, Department of Health.
Reply Date: 2000/11/16
More Info
Pediatric purpura, particularly in infants, can be a concerning condition for parents. It is characterized by the appearance of purple spots or bruises on the skin due to bleeding underneath. In your child's case, the sudden onset of petechiae (small red or purple spots) and a critically low platelet count (thrombocytopenia) necessitated immediate medical attention, which is crucial in such scenarios.
1. Causes and Types of Purpura
Your child's presentation raises questions about the underlying cause of the purpura. In infants, purpura can arise from various causes, including:
- Immune Thrombocytopenic Purpura (ITP): This is an autoimmune condition where the immune system mistakenly attacks platelets. It can occur after a viral infection, even if the child does not exhibit typical cold symptoms.
- Vascular Disorders: Conditions like Henoch-Schönlein purpura (HSP) can cause purpura and are often associated with abdominal pain and joint symptoms.
- Infections: Certain infections can lead to thrombocytopenia and purpura.
- Allergic Reactions: While allergic purpura is less common, it can occur in response to medications or infections.
Given that your child did not have any preceding illness, it is less likely to be an allergic purpura. The fact that the platelet count improved with treatment suggests that it may have been a case of ITP or another transient condition.
2. Recurrence and Follow-Up
Regarding the concern about recurrence, while many cases of ITP in children resolve spontaneously, there is a possibility of recurrence, especially if the underlying cause is not fully understood. Regular follow-ups with your pediatrician or a pediatric hematologist are essential to monitor platelet levels and overall health.
3. Vaccination Schedule
As for vaccinations, it is generally recommended to wait until the platelet count is stable and normal before proceeding with routine immunizations. Since your child has been off steroids for two weeks and has shown improvement, consult your pediatrician about the appropriate timing for vaccinations. They will likely assess your child's current health status and platelet count before proceeding.
4. Normal Blood Values for Infants
For a four-month-old infant, the normal ranges for blood values are approximately:
- White Blood Cells (WBC): 6,000 to 17,500 cells per microliter
- Red Blood Cells (RBC): 4.1 to 6.1 million cells per microliter
- Hemoglobin (HGB): 10.0 to 14.0 grams per deciliter
- Platelets (PLT): 150,000 to 450,000 platelets per microliter
Your child's platelet count of 3,000 was critically low, and it is reassuring that it has returned to normal levels. Regular blood tests may be necessary to ensure that these values remain stable.
5. Care and Monitoring
In terms of care, it is crucial to monitor your child for any signs of bleeding or bruising, especially as they begin to become more active. Avoid activities that could lead to injury, and ensure that any new medications or vaccinations are discussed with your healthcare provider.
In summary, pediatric purpura can be a complex condition requiring careful monitoring and management. Regular follow-ups with your healthcare provider, attention to vaccination schedules, and awareness of your child's overall health are essential steps in ensuring their well-being. If you have any further concerns or if your child exhibits any new symptoms, do not hesitate to seek medical advice promptly.
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