the Side Effects of Stilnox and Alternatives Like Ativan for Insomnia - Psychiatry

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Insomnia


My wife has poor sleep quality, and the doctor prescribed Stilnox.
However, she has heard about its side effects and is reluctant to take it.
What are the actual side effects of this medication? How safe is Ativan? Can it be used as a substitute?

Shen, 60~69 year old female. Ask Date: 2005/04/03

Dr. Yu Xie Zhao reply Psychiatry


Stinox is a new type of sleeping pill that has gained popularity in recent years, claiming to be less addictive and to increase deep sleep duration.
However, the response to any medication varies from person to person.
Ativan is an older medication belonging to the benzodiazepine (BZD) class, primarily used for anxiety relief.
It has a high safety profile and does not significantly increase liver burden.
If your wife finds Ativan effective, her level of dependence on the medication may be low; however, it is important to remind you that these medications can be addictive and should not be used long-term or in large quantities.

Reply Date: 2005/04/03

More Info


When it comes to treating insomnia, medications like Stilnox (also known as Zolpidem) and Ativan (Lorazepam) are commonly prescribed. However, both medications come with their own set of side effects and considerations regarding safety and dependency.

Stilnox (Zolpidem) is a non-benzodiazepine hypnotic that is often favored for its ability to induce sleep quickly and improve sleep quality without the extensive hangover effects associated with some older sleep medications. However, it is important to note that while it is marketed as having a lower risk of dependence compared to traditional benzodiazepines, there are still significant concerns. Common side effects of Stilnox include:
1. Drowsiness: While this is the intended effect, it can persist into the next day, affecting daily activities.

2. Dizziness: Some users report feeling dizzy, which can increase the risk of falls, especially in older adults.

3. Memory Issues: There have been reports of anterograde amnesia, where users may not remember events that occurred after taking the medication.

4. Sleepwalking or Other Complex Behaviors: Some individuals have been known to engage in activities like driving or cooking while not fully awake, leading to potentially dangerous situations.

5. Dependency: Although the risk is lower than with benzodiazepines, there is still a risk of developing a tolerance and dependence with prolonged use.

Ativan (Lorazepam), on the other hand, is a benzodiazepine that is often used for anxiety but can also be effective for insomnia. Its safety profile is generally considered to be good when used as prescribed, but it also carries risks. Common side effects include:
1. Sedation: Similar to Stilnox, Ativan can cause significant drowsiness, which may affect daytime functioning.

2. Cognitive Impairment: Users may experience confusion, especially in older adults, which can lead to falls or accidents.

3. Dependency and Withdrawal: Benzodiazepines like Ativan can lead to physical dependence, and stopping the medication suddenly can result in withdrawal symptoms, including rebound insomnia and increased anxiety.

4. Respiratory Depression: In higher doses or when combined with other depressants (like alcohol), Ativan can depress breathing, which is a serious risk.

In terms of whether Ativan can be a suitable alternative to Stilnox, it depends on your wife's specific situation. If she has anxiety contributing to her insomnia, Ativan might be beneficial. However, it is crucial to use it under strict medical supervision due to the potential for dependence and withdrawal issues.
If your wife is concerned about the side effects of Stilnox, it may be worth discussing alternative treatments with her healthcare provider. Non-pharmacological approaches, such as cognitive-behavioral therapy for insomnia (CBT-I), lifestyle modifications (like improved sleep hygiene), and relaxation techniques, can be effective and carry fewer risks than medications.

In conclusion, both Stilnox and Ativan have their pros and cons, and the choice between them should be made based on a thorough discussion with a healthcare provider, considering your wife's medical history, current medications, and personal preferences. It is also essential to monitor her response to any medication closely and to consider non-drug interventions for insomnia.

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