Concerns About CETIN F.C. Tablet: Accumulation and Fertility Questions - Pharmacology

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Skin medication inquiry~~~~ urgent question


Hello, Pharmacist Hou:
I would like to consult with you.
Today, I visited a dermatologist for skin itching, and the doctor prescribed a medication called CETIN F.C.
TABLET, 1.00 tablet once daily for a total of five days.
The doctor inquired about any considerations regarding future pregnancies.
Although I had no questions at the time, I found the doctor's inquiry a bit strange.
I would like to ask if this medication accumulates in the body for a long time.
I plan to have my second child in two years.
Will this medication remain in my system for an extended period? I feel a bit awkward asking this, but since the doctor did not provide much explanation, I am left with some concerns.
I would greatly appreciate your response.
Thank you very much!

kiki, 20~29 year old female. Ask Date: 2005/04/10

Dr. Hou Fangmin reply Pharmacology


Hello; I understand that you are feeling anxious, and I appreciate your concerns.
Pregnancy categories are classified as A, B, C, D, and X.
Cetirizine is classified as a Category B medication during pregnancy, which means it is considered safe to use.
It reaches peak levels in the body one hour after ingestion, with approximately 60% of the drug excreted unchanged in urine within 24 hours and 5% eliminated in feces.
The half-life of cetirizine is about 7.4 hours.
Therefore, if you take this medication, it will be eliminated from your system relatively quickly, and it should not affect your future pregnancies.
Thank you for your question.
Goodbye.

Reply Date: 2005/04/10

More Info


CETIN F.C. Tablet, which contains cetirizine, is an antihistamine commonly used to relieve symptoms of allergies, such as itching and hives. Your concerns about the potential accumulation of this medication in your body and its effects on fertility are valid, especially considering your plans for future pregnancies.

Firstly, it's important to understand how cetirizine works and its pharmacokinetics. Cetirizine is classified as a Category B medication during pregnancy, which means that animal reproduction studies have not shown any adverse effects on the fetus, and there are no adequate and well-controlled studies in pregnant women. This classification suggests that cetirizine is generally considered safe for use during pregnancy, although it is always best to consult with your healthcare provider regarding any medications you plan to take while trying to conceive or during pregnancy.

Regarding the accumulation of cetirizine in the body, cetirizine has a relatively short half-life of approximately 7.4 hours. This means that the drug is eliminated from the body fairly quickly, with about 60% of the drug being excreted in urine within 24 hours. Given this pharmacokinetic profile, it is unlikely that cetirizine will accumulate in your body over time, especially with the prescribed dosage of one tablet per day for five days. After completing the course of treatment, cetirizine should be cleared from your system within a few days.

Your physician's inquiry about your reproductive plans may stem from a cautious approach to prescribing medications that could potentially affect pregnancy or fetal development. While cetirizine is generally considered safe, it is always prudent for healthcare providers to assess any potential risks associated with medications, especially in women of childbearing age.

If you are planning to conceive in the next two years, it is essential to maintain open communication with your healthcare provider. They can provide personalized advice based on your medical history and current health status. If you have any lingering concerns about the use of cetirizine or any other medications, discussing them with your doctor can help alleviate your worries and ensure that you are making informed decisions about your health and future pregnancies.

In summary, CETIN F.C. Tablet (cetirizine) is unlikely to accumulate in your body and is generally considered safe for use in women planning to conceive. However, it is always best to consult with your healthcare provider for personalized advice and to address any specific concerns you may have regarding fertility and medication use. Your health and the health of your future children are paramount, and your healthcare provider can help guide you through this process.

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