Concerns About Medication Use During Early Pregnancy: Seeking Guidance - Obstetrics and Gynecology

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Dear Dr.
Lu,
My husband and I were previously advised by a gynecologist that we would need to undergo in vitro fertilization (IVF) to have our own baby, as my husband's sperm count was below 5 million with up to 90% abnormal morphology.
After continuous monitoring, a doctor discovered that he had varicocele, and he underwent surgery in June.
I have also been focusing on improving my health; from February to June, I visited a traditional Chinese medicine practitioner for herbal supplements.
However, I may have overdone it with the supplements, as I started experiencing significant acne in July.
I consulted a dermatologist and was prescribed Doxycycline, starting with two pills a day (from July 7 to July 21).
After some improvement, the dosage was reduced to one pill a day (from July 21 to August 11).
The doctor then switched my medication to one Bory Mycin Pellet a day (from August 11 to September 7).

During this time, I was less preoccupied with fertility issues, and on September 9, I discovered that my period was late.
A pregnancy test confirmed that I am pregnant.
My last menstrual period started on August 9, with cycles typically ranging from 27 to 29 days, so I estimate conception likely occurred around August 21.
I continued taking one Bory Mycin Pellet daily until September 7.
While I am thrilled that my husband and I can conceive naturally, I am also very concerned about the potential risks of the medication leading to birth defects.
My emotions are quite complicated, and I have been feeling quite distressed lately.
I reached out to my dermatologist, who believes that since I discovered the pregnancy early and immediately stopped the medication, and given the low dosage, it should be okay.
He mentioned that Bory Mycin Pellet primarily affects the development of the fetus's teeth and bones (in the later stages).
However, he still advised me to consult with my gynecologist for further guidance.

Do you have any recommendations? I truly feel helpless right now.
~><~

Xiao Xuan, 30~39 year old female. Ask Date: 2011/09/13

Dr. Lü Lizheng reply Obstetrics and Gynecology


Dear Xiaoxuan,
Hello, Bory Mycin Pellet primarily affects the development of fetal teeth and bones, but it must be taken during the later stages of pregnancy.
You are currently only a few weeks pregnant, and the embryo is still in the stage of a cluster of cells, with no organ differentiation yet, so it will not be affected.
Since you are aware and have stopped the medication early, there is no need to worry.
Wishing you safety and health,
Dr.
Lu Lizheng
Director, Department of Obstetrics and Gynecology
Taoyuan General Hospital, Ministry of Health and Welfare

Reply Date: 2011/09/13

More Info


When it comes to medication use during early pregnancy, it is essential to approach the topic with caution and informed guidance. The concerns you have regarding the medications you took prior to and during the early stages of your pregnancy are valid and deserve careful consideration.

Firstly, it is important to understand that the first trimester of pregnancy is a critical period for fetal development. During this time, the embryo is particularly vulnerable to teratogenic effects, which are adverse effects that can lead to birth defects. The risk of these effects is often highest during the first 8 to 10 weeks of gestation, as this is when the major organs and systems are forming.

In your case, you mentioned taking Doinmycin and Bory Mycin Pellet. Doinmycin (likely a misspelling of Doxycycline) is a tetracycline antibiotic that is generally classified as Category D in pregnancy, which means there is evidence of risk to the fetus. Specifically, tetracyclines can affect bone and tooth development in the fetus, particularly if taken during the second and third trimesters. However, the risk during the first trimester is less clear, and the potential for harm is generally considered lower than during later stages of pregnancy.
Bory Mycin Pellet, which appears to be a brand name for another antibiotic, may also have implications for fetal development. As you noted, your dermatologist indicated that the primary concerns with this medication relate to the development of teeth and bones, which typically occurs later in pregnancy. However, it is still prudent to err on the side of caution and consult with your obstetrician or a maternal-fetal medicine specialist, who can provide tailored advice based on your specific situation.

The fact that you stopped taking the medications upon discovering your pregnancy is a positive step. Early intervention is crucial, and your healthcare providers will likely monitor your pregnancy closely to ensure both your health and that of your baby. It is also important to communicate openly with your obstetrician about any medications you have taken, as they can assess the potential risks and benefits and provide you with the most accurate information.

In addition to medication concerns, it is vital to focus on overall prenatal care. This includes maintaining a healthy diet, managing stress, and attending regular prenatal appointments. These steps can help mitigate some of the risks associated with medication use and promote a healthy pregnancy.

Lastly, it is understandable to feel anxious about the potential effects of medications on your pregnancy. However, it is essential to remember that many women have taken medications during early pregnancy and have had healthy babies. The key is to work closely with your healthcare team, who can provide reassurance and guidance tailored to your unique circumstances.

In summary, while there are valid concerns regarding medication use during early pregnancy, it is crucial to consult with your healthcare providers for personalized advice. They can help you navigate your worries and ensure that you receive the best care possible for both you and your baby.

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