When Will Side Effects of Psychiatric Medications Disappear? - Psychiatry

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When do side effects subside?


Hello Doctor: I have taken the following medication (in the evening), and after two days, I have experienced drowsiness during the day.
The medication is "You-Jet F.C.
Tablets 50 mg" (Sertraline).
How long will this drowsiness last? Would it be better to take half the dose? Is that feasible?

wiwi, 20~29 year old female. Ask Date: 2005/05/04

Dr. Wang Chongren reply Psychiatry


Dear Dr.
Wang Chong-Ren of the Psychiatric Department at Tainan Hospital,
In response to your letter regarding the daytime drowsiness experienced after taking the medication Ujie enteric-coated tablets, I would like to inquire if you are taking any other medications during the day.
Generally, this medication can occasionally cause daytime drowsiness.
It may be beneficial to take the medication at bedtime instead, and typically, this side effect improves after about a week.
If the issue persists, considering a reduction in dosage by half may be advisable.

Wishing you good health and all the best from the Psychiatric Department at Tainan Hospital!

Reply Date: 2005/05/04

More Info


When it comes to psychiatric medications, understanding the timeline for side effects to dissipate can be quite complex. The duration of side effects largely depends on the specific medication, the dosage, individual metabolism, and how long the medication has been taken.
In your case, you mentioned taking Sertraline and another medication, which I assume is a form of Venlafaxine (often referred to as "N.K." in some contexts). Both of these medications belong to different classes of antidepressants: Sertraline is a selective serotonin reuptake inhibitor (SSRI), while Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI).

Side Effects Timeline
1. Initial Side Effects: For many patients, side effects such as drowsiness, nausea, or dizziness can occur shortly after starting the medication, often within the first few days. These initial side effects may subside as your body adjusts to the medication, typically within 1-2 weeks.

2. Long-term Side Effects: Some side effects may persist longer, especially if the medication is taken at a higher dose. For instance, drowsiness or fatigue can linger for several weeks, particularly with medications that have sedative properties.
3. Dose Adjustment: Reducing the dosage can sometimes alleviate side effects. However, it’s crucial to consult with your prescribing physician before making any changes to your medication regimen. Lowering the dose may reduce side effects, but it could also impact the medication's efficacy in managing your symptoms.
4. Withdrawal Symptoms: If you decide to stop or significantly reduce your medication, be aware of potential withdrawal symptoms, which can include increased anxiety, mood swings, or even a return of depressive symptoms. This is particularly relevant for medications like Venlafaxine, which can have withdrawal effects if not tapered properly.


Recommendations
- Consult Your Doctor: Before making any changes to your medication, including dosage adjustments, it’s essential to have a discussion with your healthcare provider. They can provide guidance tailored to your specific situation and help you weigh the benefits and risks of continuing or adjusting your current treatment.

- Monitor Your Symptoms: Keep a journal of your symptoms and any side effects you experience. This information can be invaluable for your doctor in determining the best course of action.

- Consider Therapy: In addition to medication, therapy can be an effective way to manage psychiatric conditions. Cognitive-behavioral therapy (CBT) or other forms of psychotherapy can help address underlying issues and improve coping strategies.

- Lifestyle Adjustments: Incorporating healthy lifestyle changes, such as regular exercise, a balanced diet, and good sleep hygiene, can also help mitigate some side effects and improve overall mental health.


Conclusion
In summary, the timeline for side effects to disappear can vary widely among individuals and medications. While some side effects may resolve within a week or two, others may take longer. Always consult with your healthcare provider before making any changes to your medication regimen to ensure that you are managing your mental health effectively and safely. Remember, managing psychiatric conditions often requires a multifaceted approach, including medication, therapy, and lifestyle changes.

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