Ankylosing spondylitis
Hello Doctor, I inquired about an issue a few days ago, and today the report has come out (B27 is negative).
I would like to ask about my current condition.
Between September and December of last year, I frequently experienced a feeling of chest tightness upon waking up, as well as lower back pain.
Besides the mornings, I also experienced lower back pain at night before going to sleep.
Recently, however, I have been experiencing back pain before bed, and my legs feel numb.
I also have a feeling of pressure in my chest upon waking, but it is not as frequent as last year.
In March of this year, an ophthalmologist diagnosed me with iritis, and upon their recommendation, I went to the hospital for blood tests, but I delayed until June to get checked.
The results showed that B27 is negative, and a bone scan indicated inflammation in my heels, lower back, and chest.
Additionally, my spine appears as follows: ...
<=== The first vertebra is slightly misaligned)______)______)___)___ P.S.
This is viewed from the arm's perspective, not from the back (of course, it’s not misaligned to such an exaggerated degree).
What should I do now, and what could possibly be the issue?
yidan, 20~29 year old female. Ask Date: 2005/06/10
Dr. Zhou Lizhi reply Orthopedics
Based on your description, there is a strong suspicion of an autoimmune disease (HLA B27 negative sero-negative) that may affect the eyes, salivary glands, and other connective tissues.
Comprehensive treatment should be conducted by a specialist in immunology, and the inflammation in the spine is also likely to be treated primarily with medication.
Reply Date: 2005/06/10
More Info
It sounds like you are experiencing a complex set of symptoms that could be related to several underlying conditions. The combination of back pain, chest pressure, and leg numbness, particularly when associated with inflammation in your spine and previous episodes of iritis (inflammation of the iris), raises several possibilities that warrant further investigation.
Understanding Your Symptoms
1. Back Pain and Inflammation: Your symptoms of back pain, particularly when waking up or going to bed, could be indicative of a condition known as ankylosing spondylitis (AS), which is a type of inflammatory arthritis that primarily affects the spine and can lead to severe, chronic pain and discomfort. Although your HLA-B27 test came back negative, it is important to note that not all patients with AS test positive for this marker. The presence of inflammation in your bone scan, particularly in the spine, suggests that there may be an inflammatory process at play.
2. Chest Pressure: The sensation of chest pressure upon waking could be related to musculoskeletal issues, such as muscle strain or inflammation affecting the thoracic spine. However, it is essential to rule out any cardiac issues, especially if the sensation is new or has changed in character. If you experience any additional symptoms such as shortness of breath, palpitations, or radiating pain, it would be prudent to seek immediate medical attention.
3. Leg Numbness: Numbness in the legs can be caused by nerve compression, which may occur due to spinal issues, such as herniated discs or spinal stenosis. Given your history of back pain and the findings from your bone scan, it is possible that inflammation or structural changes in your spine are contributing to nerve compression, leading to the numbness you are experiencing.
Next Steps
1. Consult a Rheumatologist: Given your symptoms and the findings from your tests, it would be beneficial to consult a rheumatologist. They specialize in autoimmune and inflammatory conditions and can provide a comprehensive evaluation of your symptoms. They may recommend additional tests, such as MRI imaging of the spine, to assess for inflammation or structural changes that could be contributing to your symptoms.
2. Physical Therapy: Engaging in physical therapy may help alleviate some of your symptoms. A physical therapist can design a program tailored to your needs, focusing on strengthening the muscles around your spine, improving flexibility, and reducing inflammation.
3. Pain Management: Depending on the severity of your pain, your healthcare provider may recommend medications to help manage your symptoms. Nonsteroidal anti-inflammatory drugs (NSAIDs) can be effective for reducing inflammation and pain. In some cases, disease-modifying antirheumatic drugs (DMARDs) or biologics may be considered if an inflammatory arthritis diagnosis is confirmed.
4. Lifestyle Modifications: Incorporating regular exercise, maintaining a healthy weight, and practicing good posture can also help manage symptoms. Activities such as swimming, walking, or yoga may be beneficial for maintaining mobility and reducing stiffness.
5. Monitoring Symptoms: Keep a detailed record of your symptoms, including when they occur, their severity, and any potential triggers. This information can be invaluable for your healthcare provider in determining the best course of action.
Conclusion
Your symptoms are multifaceted and suggest the possibility of an inflammatory condition affecting your spine and possibly other areas of your body. It is crucial to pursue further evaluation with a specialist who can help clarify the diagnosis and guide you toward appropriate treatment options. Early intervention can significantly improve your quality of life and prevent potential complications related to untreated inflammatory conditions. Please ensure you follow up with your healthcare provider to discuss your symptoms and the best path forward.
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