Concerns About Long-Term Medication Use for Wright's Syndrome

Q: Concerns About Long-Term Medication Use for Wright's Syndrome

Hello： Regarding reactive arthritis (Reiter's syndrome) with serological findings of Chlamydia infection, if there are no symptoms of Chlamydia infection, theoretically, treatment may not be necessary, and you would not need to take antibiotics for an extended period. <br>Please

Medication issues

Hello, doctor.
I previously asked you some questions, and today I have a few more...
I have been diagnosed with Wright's syndrome.
During my follow-up appointment today, the doctor prescribed me antibiotics (Sinflo), a gastric medication, and an immunomodulator (Salazopyrin).
I asked the doctor, and she said I need to take the medication continuously for three months.
Since I have follow-up appointments every two weeks, the prescribed amount is for two weeks of Sinflo, two weeks of the gastric medication, and one week of antibiotics.
My question is, if I need to take the antibiotics continuously for three months, that means I will be on antibiotics for a total of one and a half months, in addition to my regular medications for acid reflux (potent acid suppressants and medications for lower esophageal sphincter contraction) and Loperamide.
Will this have a negative impact on my liver and kidney function?

guest, 20~29 year old female. Ask Date: 2005/08/10

Dr. Lin Xiaoyi reply Orthopedics

Hello: Regarding reactive arthritis (Reiter's syndrome) with serological findings of Chlamydia infection, if there are no symptoms of Chlamydia infection, theoretically, treatment may not be necessary, and you would not need to take antibiotics for an extended period.
Please discuss this with your physician.
Additionally, some individuals who take Salazopyrin and Finasteride long-term may experience abnormal liver function, but this is more common in those who already have pre-existing liver issues.
Physicians will regularly monitor liver and kidney function, so there is no need for concern.
Lin Hsiao-Yi, Department of Allergy, Immunology, and Rheumatology, Taipei Veterans General Hospital.

Reply Date: 2005/08/10

More Info

Wright's syndrome, also known as Wright's disease, is a complex condition that can involve various symptoms, including joint pain and inflammation. The management of this syndrome often requires a combination of medications, including immunomodulators like salazopyrin, antibiotics, and gastric medications. Your concerns about the long-term use of these medications, particularly regarding their effects on liver and kidney function, are valid and important to address.

First, let's discuss the medications you mentioned. Salazopyrin (sulfasalazine) is commonly used to treat inflammatory conditions, including rheumatoid arthritis and inflammatory bowel disease. It works by modulating the immune response and reducing inflammation. While it can be effective, long-term use may lead to side effects, including potential liver toxicity and blood dyscrasias. Regular monitoring of liver function tests and complete blood counts is essential while on this medication.

Antibiotics, such as the one you referred to (sinflo, which may contain levofloxacin), are typically prescribed for bacterial infections. Long-term use of antibiotics can disrupt the normal gut flora, leading to gastrointestinal issues and potentially increasing the risk of antibiotic resistance. It's crucial to use antibiotics judiciously and only for the duration necessary to treat the infection. If you are prescribed antibiotics for an extended period, your healthcare provider should monitor you for any adverse effects, including effects on liver and kidney function.

Regarding your use of gastric medications, proton pump inhibitors (PPIs) and other acid-reducing agents can be effective for managing gastroesophageal reflux disease (GERD) and other acid-related disorders. However, long-term use of PPIs has been associated with certain risks, including potential kidney disease, nutrient malabsorption (such as magnesium and vitamin B12), and increased risk of gastrointestinal infections. Therefore, it's essential to evaluate the necessity of continued PPI therapy with your healthcare provider.

As for your concern about the cumulative effects of these medications on your liver and kidney function, it is important to have regular follow-ups with your healthcare provider. They can perform blood tests to monitor your liver enzymes, kidney function (creatinine and electrolytes), and overall health status. If any abnormalities are detected, your doctor may adjust your medication regimen accordingly.

In summary, while long-term medication use for Wright's syndrome is often necessary to manage symptoms and prevent flares, it is crucial to do so under the guidance of a healthcare professional. Regular monitoring of liver and kidney function, as well as being vigilant about potential side effects, will help ensure that your treatment remains safe and effective. If you have concerns about your current medication regimen, do not hesitate to discuss them with your doctor. They can provide personalized advice and may consider alternative treatments or adjustments to your current medications based on your health status and response to treatment.

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