Can Hepatitis B Be Transmitted Through Saliva? Antibody Longevity - Internal Medicine

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Is hepatitis B transmissible through saliva?


Is hepatitis B transmissible through saliva? Can hepatitis B antibodies disappear over time and lead to reinfection? Are there lifelong hepatitis B antibodies?

mimi, 30~39 year old female. Ask Date: 2005/09/07

Dr. Xiao Jingqin reply Internal Medicine


Transmission routes of Hepatitis B: 1.
Vertical transmission - If a mother is a carrier of Hepatitis B, she may transmit the virus to the fetus before or during delivery.
2.
Horizontal transmission - Hepatitis B can also be transmitted through blood transfusions, injections, ear piercing, tattoos, eyebrow tattoos, and sharing personal items such as toothbrushes, towels, nail clippers, and razors in daily life.
Approximately 1% of carriers lose their antigens each year and develop antibodies.
However, long-term clinical observations have shown that the disappearance of these antigens is often due to very low concentrations in the serum, which may not be detectable even with the most sensitive testing methods.
Nevertheless, using DNA probe testing may reveal the presence of the Hepatitis B virus, leading to the term "low-level Hepatitis B surface antigen carriers." In reality, these individuals remain infected with the Hepatitis B virus, and we should not take this lightly.

Reply Date: 2005/09/07

More Info


Hepatitis B is primarily transmitted through blood and certain body fluids, including semen and vaginal secretions. The transmission through saliva is considered to be very low risk. While Hepatitis B virus (HBV) can be found in saliva, the concentration is significantly lower than in blood. Therefore, casual contact, such as kissing or sharing utensils, does not typically pose a risk for transmission. The primary routes of transmission include vertical transmission from mother to child during childbirth, sharing needles, and sexual contact with an infected person.

Regarding the longevity of Hepatitis B antibodies, it is important to distinguish between the different types of antibodies produced in response to the virus. When a person is infected with Hepatitis B and recovers, their body produces antibodies, specifically Hepatitis B surface antibodies (anti-HBs), which provide immunity against future infections. In most cases, these antibodies can last for a lifetime, providing long-term protection. However, there are instances where antibody levels may decline over time, particularly in individuals who were vaccinated.
Studies have shown that about 5-10% of vaccinated individuals may lose detectable anti-HBs levels within 5 to 10 years after vaccination. However, even if the antibodies are no longer detectable, memory B cells remain in the body. If the individual is later exposed to the virus, these memory cells can quickly respond by producing new antibodies, thus providing a level of protection.

In terms of the risk of reinfection, individuals who have recovered from Hepatitis B and have developed anti-HBs are generally considered immune. However, there are rare cases where individuals can be reinfected with a different strain or subtype of the virus, especially if their immune system is compromised. This is more common in individuals who have underlying health conditions or are on immunosuppressive therapies.

In conclusion, while Hepatitis B can theoretically be present in saliva, the risk of transmission through this route is extremely low. The presence of Hepatitis B antibodies typically indicates immunity, and while levels may decline over time, the body retains the ability to respond to future exposures. Regular monitoring and vaccination are recommended for individuals at risk or those who may have been exposed to the virus, especially in high-risk situations. If there are concerns about potential exposure or antibody levels, consulting a healthcare provider for testing and advice is advisable.

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