Managing Hepatitis C: What to Do After Diagnosis - Internal Medicine

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How to cope with hepatitis C?


My mother, who is in her sixties, was tested at a health clinic and found to have a hepatitis C index of 5.
The clinic only advised her to return for a follow-up test in five weeks.
Should we just wait for that?

lina, 30~39 year old female. Ask Date: 2005/10/05

Dr. Xiao Jingqin reply Internal Medicine


Currently, there is a new treatment for hepatitis C that involves a combination therapy of long-acting interferon and antiviral medications.
Generally, treatment is considered for individuals under 65 years of age who have persistent liver function abnormalities for more than six months (with liver function tests at least twice the upper limit of normal, typically around 100 or higher).
The treatment for hepatitis C is only being trialed in a few designated hospitals, and a liver biopsy must show liver fibrosis before interferon can be administered.
Additionally, side effects from interferon treatment are quite common.
Regarding the hepatitis index of 5, does it refer to liver function? (AST/ALT?) If the AST/ALT ratio is 5, no specific treatment is necessary.

Reply Date: 2005/10/05

More Info


After receiving a diagnosis of Hepatitis C, particularly with a reported index of 5, it is essential to take a structured approach to manage the condition effectively. Here’s a comprehensive guide on what steps to take following the diagnosis:
1. Understanding the Diagnosis: The index value of 5 suggests a positive result for Hepatitis C. However, it is crucial to confirm this diagnosis through further testing. The initial test typically detects antibodies (Anti-HCV) to the virus, but it does not indicate whether the virus is currently active or the extent of liver damage.

2. Follow-Up Testing: It is advisable to follow up with additional tests to determine the presence of the virus (HCV RNA test) and assess liver function. This includes:
- HCV RNA Test: This test measures the amount of Hepatitis C virus in the blood and confirms whether the infection is active.

- Liver Function Tests: These tests measure enzymes (like ALT and AST) to assess liver health.

- HCV Genotype Test: This identifies the specific strain of the virus, which can influence treatment decisions.

- Liver Imaging: An ultrasound or FibroScan may be recommended to evaluate liver stiffness, which indicates fibrosis or cirrhosis.

3. Consult a Specialist: It is crucial to consult a hepatologist or a gastroenterologist who specializes in liver diseases. They can provide a comprehensive evaluation and guide treatment options based on the test results.

4. Understanding Treatment Options: If the HCV RNA test confirms an active infection, treatment options will be discussed. The standard treatment for Hepatitis C has evolved significantly, with direct-acting antiviral (DAA) medications being highly effective. These treatments can lead to a sustained virologic response (SVR), meaning the virus is undetectable in the blood after treatment.

5. Monitoring and Lifestyle Changes: While waiting for follow-up tests, it is essential to monitor any symptoms and maintain a healthy lifestyle. This includes:
- Avoiding alcohol, which can exacerbate liver damage.

- Eating a balanced diet rich in fruits, vegetables, and whole grains.

- Staying hydrated and engaging in regular physical activity.

- Avoiding medications that can harm the liver unless prescribed by a healthcare provider.

6. Emotional Support: A diagnosis of Hepatitis C can be overwhelming. It is important to seek emotional support from family, friends, or support groups. Many organizations provide resources and community support for individuals living with Hepatitis C.

7. Regular Follow-Up: After the initial follow-up tests, regular monitoring of liver function and overall health is crucial. This may include periodic blood tests and imaging studies as recommended by the healthcare provider.

In summary, while waiting for the follow-up appointment, it is essential to stay informed about the condition, maintain a healthy lifestyle, and prepare for discussions about further testing and potential treatment options. Engaging with healthcare professionals and understanding the implications of the diagnosis will empower your mother to take proactive steps in managing her health.

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