Medication overdose..?
A 53-year-old male patient with gout visited the rheumatology and immunology department of the hospital.
He picked up his medication from the pharmacy at 13:47 and took the medication at home at 15:30.
Within 30 minutes, he began to experience dizziness and vomited brown material.
Approximately 30 minutes later, he vomited a large amount of brown material again.
Concerned about these symptoms, he contacted the hospital's medication consultation hotline to inquire why he was experiencing these effects after taking the medication.
The consultation response indicated that the medication should not cause such effects and suggested it might be due to food poisoning.
Around 17:00, he vomited an even larger volume of brown material for the third time.
About 15 minutes later, he passed a large amount of brown material.
The patient was in a semi-comatose state, prompting him to seek care from the gastroenterology department around 18:30, and he was subsequently transferred to the emergency department.
During the emergency examination, his blood pressure had dropped below 80, and his hemoglobin level was approximately 7-8, indicating possible acute internal bleeding.
He was admitted to the hospital the following day and underwent examination and treatment for five days before being discharged to rest at home.
It was later discovered that there was an error in the prescription bag; the bag contained Taiwan's Tanabe Seiyaku's Hibi-Stop 30mg instead of the prescribed COLCHICINE 0.5MG/TAB.
The patient had no prior gastrointestinal issues.
Could you please advise if the episode was related to the Hibi-Stop 30mg (the patient only took one tablet)?
QQ, 50~59 year old female. Ask Date: 2005/12/05
Dr. Hou Fangmin reply Pharmacology
Hello; The mechanism of action of Herbesser: This medication is a "calcium channel blocker" that causes vasodilation, allowing more blood to flow smoothly through the blood vessels, thereby achieving the goal of lowering blood pressure.
Side effects: Generally, side effects are rare, and if they do occur, they are usually mild.
Commonly reported side effects include bradycardia, nausea, and headache.
Colchicine: It reduces uric acid crystals and inflammatory responses.
Side effects: 1.
Long-term use: Occasionally, symptoms such as leukopenia, myopathy, peripheral neuropathy, hematuria, and oliguria may occur.
2.
Allergic reactions: Sometimes, symptoms such as generalized itching, rash, and fever may occur.
3.
Gastrointestinal: There may occasionally be more severe gastrointestinal disturbances.
Side effects of medications vary from person to person.
The likelihood of gastrointestinal side effects from Herbesser is very low, and it does not cause gastrointestinal bleeding.
Moreover, a single dose is only 30 mg, which should not lead to such severe side effects.
If one pill could cause such severe reactions, it would need to be classified as a controlled substance.
Furthermore, Herbesser is also available in a 90 mg dosage, and using it twice a day should not lead to such issues.
I suspect that the long-term use of Colchicine may predispose you to gastrointestinal bleeding due to peptic ulcers, which could lead to these side effects.
Since bleeding can cause a drop in blood pressure and a decrease in hemoglobin levels, I recommend that you consult your original physician for a thorough examination regarding your gastrointestinal issues.
Wishing you safety and good health.
Reply Date: 2005/12/05
More Info
Medication errors can have serious consequences for patients, as illustrated by the case of a 53-year-old male patient who experienced severe adverse effects after taking a medication that was incorrectly dispensed. In this situation, the patient was prescribed Colchicine for gout but received a different medication, which led to a series of alarming symptoms, including dizziness, vomiting of brown material, and ultimately a state of semi-consciousness due to acute internal bleeding.
The first step in understanding the risks and consequences of medication errors is to recognize that they can occur at various points in the medication management process, including prescribing, dispensing, and administration. In this case, the error occurred during the dispensing phase, where the patient received a medication that was not intended for him. The medication he received, "合必爽" (also known as "Hapilong" or "Hapilong 30mg"), is a non-steroidal anti-inflammatory drug (NSAID) that can cause gastrointestinal irritation and bleeding, especially in patients without prior gastrointestinal issues.
The symptoms experienced by the patient—dizziness and vomiting—are not typical side effects of Colchicine, which is primarily used to treat gout flares and can cause gastrointestinal upset but not typically the severe reactions observed here. The brown vomit and stool suggest the presence of blood, indicating a potential gastrointestinal bleed, which can be a serious and life-threatening condition.
Given that the patient had no prior gastrointestinal issues, it is plausible that the administration of the NSAID contributed to the acute gastrointestinal bleeding. NSAIDs are known to increase the risk of gastrointestinal bleeding, particularly in patients who may be predisposed due to other factors such as dehydration, concurrent medications, or underlying health conditions.
In this case, the patient's rapid deterioration and the eventual diagnosis of acute internal bleeding necessitated immediate medical intervention. The fact that the patient was initially told that the medication would not cause such symptoms further complicates the situation, highlighting the importance of thorough medication counseling and monitoring.
To prevent such medication errors in the future, several strategies can be implemented:
1. Improved Communication: Clear communication between healthcare providers, pharmacists, and patients is essential. Patients should be encouraged to ask questions about their medications, including potential side effects and what to do if they experience unusual symptoms.
2. Medication Reconciliation: Healthcare providers should perform medication reconciliation at every point of care to ensure that patients receive the correct medications. This includes verifying the medication name, dosage, and indications.
3. Education and Training: Continuous education and training for healthcare professionals on the importance of accurate medication dispensing and the potential consequences of errors can help reduce the incidence of medication errors.
4. Patient Education: Patients should be educated about their medications, including what they are for, how to take them, and what side effects to watch for. This empowers patients to be active participants in their healthcare.
5. Reporting Systems: Establishing a robust system for reporting medication errors can help healthcare facilities identify patterns and implement corrective actions to prevent future occurrences.
In conclusion, the case of the 53-year-old male patient underscores the critical importance of accurate medication dispensing and the potential risks associated with medication errors. It serves as a reminder for healthcare providers to prioritize patient safety through effective communication, education, and monitoring. The relationship between the incorrect medication and the patient's adverse effects should be thoroughly investigated to ensure that similar incidents do not occur in the future.
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