Skin Blisters in Patients with Respiratory Failure - Dermatology

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The skin developed blisters all over within a day?


Hello Doctor: My father-in-law is currently in a vegetative state and requires a ventilator, as well as long-term dialysis.
Today, the respiratory care unit informed us that he has developed blisters from his genitals to his legs (a large area, resembling ulceration), with some signs of pus.
The hospital does not have a dermatology department and only advised us to purchase antibiotic ointment for application.
Since my father-in-law is on a ventilator due to respiratory failure, he often has elevated white blood cell counts and experiences fever almost daily, and he has been receiving antibiotic injections (only during pneumonia).
Based on the above description, could you help us determine the possible condition and the appropriate ointment to use? Thank you very much!

Sara, 30~39 year old female. Ask Date: 2006/02/09

Dr. Zheng Lizhen reply Dermatology


Hello: I apologize, but I cannot assess the condition and the necessary treatment at this time.
Sincerely, Dr.
Cheng Li-Chen, Dermatology.

Reply Date: 2006/02/09

More Info


Understanding skin blisters in patients with respiratory failure, especially those who are on ventilators, can be quite complex. In your case, it appears that your grandfather is experiencing significant skin issues, including blisters and possible infection, which can be attributed to several factors related to his underlying health conditions and the use of a ventilator.

Patients who are on mechanical ventilation often have compromised skin integrity due to prolonged immobility, pressure from medical devices, and potential exposure to moisture. The development of blisters, particularly in areas that are under pressure or friction, can be a sign of pressure ulcers or skin breakdown. Additionally, the presence of pus suggests a possible secondary bacterial infection, which is not uncommon in patients with weakened immune systems or those who are critically ill.

Given your grandfather's history of respiratory failure, renal issues, and recurrent fevers, it is crucial to consider the following:
1. Skin Care and Hygiene: Maintaining proper skin hygiene is essential. The areas affected should be kept clean and dry. Gentle cleansing with mild soap and water can help prevent further irritation. Avoid using harsh chemicals or scrubs that could exacerbate the condition.

2. Antibiotic Treatment: Since the hospital has recommended the use of antibiotic ointment, it is important to ensure that the specific antibiotic is appropriate for the type of infection present. If there is a concern about the effectiveness of the topical treatment, or if the condition worsens, it may be necessary to consult with a healthcare provider about systemic antibiotics, especially given the signs of infection (e.g., fever, pus).

3. Pressure Relief: If your grandfather is immobile, implementing pressure-relieving strategies is vital. This can include regular repositioning, using specialized mattresses or cushions designed to reduce pressure on vulnerable areas, and ensuring that any medical devices are properly fitted to minimize friction and pressure.

4. Nutritional Support: Proper nutrition plays a significant role in skin health and healing. If your grandfather is on dialysis, it is important to ensure that his dietary needs are being met, as malnutrition can impair wound healing and skin integrity.

5. Monitoring and Follow-Up: Continuous monitoring of the skin condition is necessary. If the blisters do not improve with topical treatment, or if there are signs of systemic infection (increased fever, changes in mental status, etc.), it is crucial to seek further medical evaluation. A dermatologist or a wound care specialist may provide more targeted treatment options.

6. Potential Underlying Conditions: The presence of blisters and skin breakdown could also indicate underlying conditions such as diabetes or vascular issues, which can affect skin health. It may be beneficial to evaluate these aspects with the healthcare team.

In conclusion, while the use of antibiotic ointment is a step in the right direction, comprehensive care involving skin hygiene, pressure relief, nutritional support, and close monitoring is essential in managing your grandfather's skin condition. If there are any concerns about the treatment plan or if the condition worsens, do not hesitate to reach out to the healthcare team for further assistance.

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