Anemia: Mediterranean vs. Iron Deficiency Types - Cardiology

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I would like to inquire about the issue of anemia?


Hello, doctor...
I participated in a school health check, and my test results are as follows: WBC 5.0, RBC 6.18, Hb 13.5, Hct 43.7, MCV 70.7, MCH 21.8, MCHC 30.8, Platelet 251.
Could you please tell me if this indicates thalassemia or iron deficiency anemia?

A-Lun, 20~29 year old female. Ask Date: 2006/03/04

Dr. Tang Jieru reply Cardiology


Hello Allen: Your test results show that your hemoglobin level (Hb=13.5) is normal, but your red blood cells are smaller than average (MCV=70.7), indicating microcytic anemia.
Both thalassemia and iron deficiency anemia are possible.
However, this test is just a routine blood test and cannot definitively identify which type you have.
You can have another blood draw to check your iron levels (Ferritin), Fe/TIBC, and serum electrophoresis to determine the specific type.
Based on your age, gender, and hemoglobin level, it seems more likely that you have thalassemia.
However, a follow-up blood test is necessary to confirm the diagnosis.
Please bring your blood test report to a hospital and consult with an internist or hematologist for further evaluation.
Thank you for your inquiry.

Reply Date: 2006/03/04

More Info


Understanding anemia, particularly the differences between Mediterranean (also known as thalassemia) and iron deficiency anemia, is crucial for proper diagnosis and treatment. Based on the provided blood test results, let's analyze the situation.

Your blood test results show:
- WBC (White Blood Cell Count): 5.0 (normal range)
- RBC (Red Blood Cell Count): 6.18 (elevated)
- Hb (Hemoglobin): 13.5 (normal range)
- Hct (Hematocrit): 43.7 (normal range)
- MCV (Mean Corpuscular Volume): 70.7 (low)
- MCH (Mean Corpuscular Hemoglobin): 21.8 (low)
- MCHC (Mean Corpuscular Hemoglobin Concentration): 30.8 (normal range)
- Platelet: 251 (normal range)

Analyzing the Results
1. Red Blood Cell Count (RBC): Your RBC count is elevated, which can sometimes be seen in conditions like thalassemia, where the body produces more red blood cells to compensate for the abnormal hemoglobin.

2. Mean Corpuscular Volume (MCV): The MCV is low (70.7), indicating microcytic anemia. This is a characteristic feature of iron deficiency anemia and thalassemia. In iron deficiency anemia, the red blood cells are smaller than normal due to insufficient iron, while in thalassemia, the body produces abnormal hemoglobin, leading to smaller red blood cells.

3. Mean Corpuscular Hemoglobin (MCH): The MCH is also low (21.8), which aligns with the findings of microcytic anemia.

4. Hemoglobin (Hb) and Hematocrit (Hct): Both values are within normal ranges, which can sometimes be seen in thalassemia, where the body compensates for the abnormal red blood cells.


Conclusion
Given the low MCV and MCH, along with the elevated RBC count, your results suggest that you may have thalassemia rather than iron deficiency anemia. However, a definitive diagnosis requires further testing, including hemoglobin electrophoresis, which can differentiate between types of hemoglobin and confirm the presence of thalassemia.


Recommendations
1. Consult a Hematologist: It is essential to consult a specialist who can interpret these results in the context of your clinical history and perform additional tests if necessary.

2. Further Testing: A hemoglobin electrophoresis test can help determine the specific type of hemoglobin present and confirm whether you have thalassemia or another form of anemia.

3. Family History: Consider discussing your family history with your doctor, as thalassemia is often inherited. Knowing if family members have had similar issues can provide valuable information for diagnosis.

4. Dietary Considerations: If iron deficiency is also a concern, ensure you are consuming iron-rich foods (like red meat, beans, and leafy greens) and vitamin C to enhance iron absorption. However, if thalassemia is confirmed, iron supplementation may not be appropriate, as it can lead to iron overload.

5. Regular Monitoring: If diagnosed with thalassemia, regular monitoring of blood counts and overall health is essential to manage any potential complications.

In summary, while your results lean towards thalassemia due to the low MCV and MCH, a thorough evaluation by a healthcare professional is necessary for an accurate diagnosis and appropriate management.

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