Laser Treatment for Melasma: Transamine vs. B12 – Which is More Effective?

Q: Laser Treatment for Melasma: Transamine vs. B12 – Which is More Effective?

Hello： Chloasma is a type of very deep pigmentation. <br>After laser treatment, post-inflammatory hyperpigmentation is inevitable. <br>Taking tranexamic acid is one method to reduce post-inflammatory hyperpigmentation. <br>As far as I know, vitamin B12 is not commonly used for th

Laser treatment for cheekbone spots?

I underwent laser treatment for my cheekbone spots three weeks ago, and they are starting to darken again.
The doctor prescribed a medication labeled as transamine, but he mentioned that it is actually B12???? Which one is more effective? Should I pay out of pocket to take both?

GIGIC, 30~39 year old female. Ask Date: 2006/05/02

Dr. Jiang Yujiao reply Dermatology

Hello: Chloasma is a type of very deep pigmentation.
After laser treatment, post-inflammatory hyperpigmentation is inevitable.
Taking tranexamic acid is one method to reduce post-inflammatory hyperpigmentation.
As far as I know, vitamin B12 is not commonly used for this purpose, although a physician may have updated medical knowledge or personal experience.
However, taking B12 is harmless to the body, so there is no need for concern.
Sincerely, Dr.
Jiang Yu-Jiao, Dermatologist.

Reply Date: 2006/05/02

More Info

When it comes to treating melasma, particularly after undergoing laser treatment, the choice of medication can significantly impact the results. In your case, you mentioned receiving a prescription for Transamine (tranexamic acid) and being told that it was actually B12. Let's break down the effectiveness of these two options and how they relate to your situation.

Transamine (Tranexamic Acid): This medication is primarily used to reduce excessive bleeding and is known for its role in treating melasma. Tranexamic acid works by inhibiting the plasminogen activation, which in turn reduces the production of melanin, the pigment responsible for skin color. Studies have shown that tranexamic acid can be effective in reducing melasma, especially when used in conjunction with other treatments like laser therapy. It is typically taken orally, and many dermatologists recommend it for patients experiencing post-inflammatory hyperpigmentation or rebound pigmentation after laser treatments.

Vitamin B12: While Vitamin B12 is essential for various bodily functions, including red blood cell formation and neurological function, it is not commonly used as a treatment for melasma. Some practitioners may suggest B12 for its overall health benefits, but it does not have a direct effect on melasma or pigmentation issues. Therefore, while taking B12 is generally safe and beneficial for overall health, it is unlikely to provide the specific benefits you are seeking for your skin condition.

Combining Treatments: Given your situation, it may be beneficial to focus on the use of Transamine for its targeted effects on melasma. If your physician has prescribed both medications, it might be worth discussing the rationale behind this decision. However, if the primary goal is to address the pigmentation issue, Transamine should be your main focus.
Considerations: When taking Transamine, it is essential to follow your doctor's instructions regarding dosage and duration. Typically, it is recommended to take it twice daily, but your healthcare provider may adjust this based on your specific needs. Additionally, while B12 is safe to take, it is advisable to consult with your doctor to ensure that there are no contraindications or interactions with other medications you may be taking.

Post-Laser Care: After laser treatment, it is crucial to protect your skin from sun exposure, as UV rays can exacerbate pigmentation issues. Using a broad-spectrum sunscreen daily is essential to prevent further darkening of the spots. Additionally, maintaining a good skincare routine that includes gentle exfoliation and hydration can support the healing process and improve overall skin appearance.

In conclusion, for treating melasma after laser treatment, Transamine is likely the more effective option compared to B12. If you have concerns about the effectiveness of either medication or the possibility of combining them, it is best to have an open discussion with your dermatologist. They can provide personalized advice based on your medical history and the specifics of your treatment plan. Always prioritize sun protection and follow your doctor's recommendations for the best outcomes in managing melasma.

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