Hepatitis B Transmission Risks in Newborns: A Parent's Concern - Pediatrics

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Hepatitis B immunoglobulin (HBIG) prophylaxis for newborns?


Hello: During the prenatal check-up, the mother of the child was screened for Hepatitis B, and the e-antigen was negative.
Doctor A indicated that the mother is a carrier but has normal liver function, and it would not affect the child (as a certain test result was not greater than or equal to 2560).
Therefore, on May 31, she gave birth to the child naturally without concern.
However, on July 8, due to jaundice and gastrointestinal issues, the child was taken to another hospital for blood tests, which revealed that the child has Hepatitis B!!! We are very confused and unable to accept this result.

1.
Could the second dose of the Hepatitis B vaccine administered on July 2 affect the test results? Is it necessary to retest?
2.
As Doctor A stated, is there truly no risk of transmission from a Hepatitis B carrier mother to the child?
3.
If there is even a slight risk, why did Doctor A not provide a warning or take action, but instead said there was no concern? Why was the child not given Hepatitis B immunoglobulin within 24 hours?
I am seeking a more impartial answer from a third party, so I kindly ask Dr.
Lin to take the time to provide clarification.
Thank you.

lukangxin, 30~39 year old female. Ask Date: 2006/07/16

Dr. Lin Huizhen reply Pediatrics


Dear lukangsin,
Hello, this is Dr.
Lin Huizhen from the Pediatrics Department of Tainan Hospital, Ministry of Health and Welfare.
1.
The presence or absence of Hepatitis B e-antigen (HBeAg) is currently used under the National Health Insurance regulations to determine eligibility for reimbursement of Hepatitis B immunoglobulin injections.
Regarding your inquiry about children contracting Hepatitis B, specific laboratory tests are required for accurate assessment, and I apologize for not being able to provide a definitive answer.
2.
The Hepatitis B vaccine should not affect the results of the assessment.
Tainan Hospital is concerned about your health.

Reply Date: 2006/07/16

More Info


Hepatitis B is a viral infection that primarily affects the liver and can lead to chronic liver disease, including cirrhosis and liver cancer. The transmission of Hepatitis B can occur through contact with infectious body fluids, such as blood, semen, and vaginal secretions. Understanding the risks associated with Hepatitis B transmission, especially in newborns, is crucial for parents and caregivers.

In your case, it appears that there are several factors at play regarding the potential transmission of Hepatitis B to your newborn. Firstly, it is important to clarify that the risk of vertical transmission (from mother to child during childbirth) is significant if the mother is a Hepatitis B carrier. However, you mentioned that your wife tested negative for the Hepatitis B surface antigen (HBsAg), which suggests that she is not a carrier of the virus. This significantly reduces the risk of transmission to the baby during delivery.

Regarding your concerns about the baby contracting Hepatitis B, it is essential to consider the timing and nature of the exposure. You indicated that there was contact between your blood and the baby's mouth before the baby received the first dose of the Hepatitis B vaccine. While Hepatitis B can be transmitted through mucous membranes, the risk of transmission in this scenario is relatively low, especially if the baby did not have any open sores or cuts in the mouth at the time of exposure. The presence of the vaccine, administered shortly after birth, also plays a critical role in protecting the newborn from infection.

1. Impact of Vaccination on Test Results: The second dose of the Hepatitis B vaccine, administered on July 2, should not affect the results of the Hepatitis B tests conducted shortly after. Vaccination typically stimulates the immune system to produce antibodies against the virus, but it does not introduce the virus itself. If the baby tested positive for Hepatitis B, it is crucial to conduct further tests to determine whether the virus is active or if the positive result is due to the vaccine.

2. Risk of Transmission from Carrier Mothers: While it is true that a mother who is a Hepatitis B carrier poses a risk of transmission to her child, your wife's negative HBsAg test indicates that she is not a carrier. Therefore, the risk of her transmitting the virus to your child is minimal. However, it is essential to ensure that all family members, especially those who may have had contact with the baby, are screened for Hepatitis B to rule out any potential sources of infection.

3. Concerns About Medical Advice: It is understandable to feel frustrated and confused about the medical advice received. If there was any indication of risk, it would have been prudent for the healthcare provider to discuss potential precautions, such as administering Hepatitis B immune globulin (HBIG) in conjunction with the vaccine, especially if there was any uncertainty regarding the mother's Hepatitis B status. The timing of vaccinations and the administration of HBIG are critical in preventing transmission in high-risk situations.

In conclusion, while the risk of Hepatitis B transmission to your newborn appears low given the circumstances, it is essential to follow up with healthcare providers for further testing and to discuss the appropriate next steps. This may include additional blood tests for the baby to confirm the presence of the virus and to assess liver function. It is also advisable to ensure that all family members are screened for Hepatitis B, and to maintain open communication with your healthcare team regarding any concerns or questions you may have. Early intervention and monitoring are key to managing any potential health issues related to Hepatitis B.

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