Hepatitis C: Questions on Diagnosis, Transmission, and Treatment - Gastroenterology and Hepatology

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Hepatitis C-related issues


Hello Doctor: My husband donated blood about ten years ago, and afterward, the blood donation center sent a notification stating that my husband tested positive for hepatitis C surface antibodies.
Since then, my husband has consistently had GOT and GPT levels around 20.
He does not smoke or drink alcohol and leads a regular lifestyle.
In retrospect, we cannot identify a source of infection.
I have undergone several health check-ups, all of which have been normal.
Doctors have advised that my husband does not need treatment and should continue to be monitored.

I would like to ask the following questions:
1.
Is it possible that there was an error at the blood donation center? Could it be that my husband was infected with hepatitis C but has since recovered?
2.
We have two children; is the risk of transmission in our daily life high? I have heard that the viral load of hepatitis C in the blood is generally lower than that of hepatitis B, making it less contagious.
Is this correct? I have also read that the likelihood of children contracting hepatitis C is lower than that of adults.

3.
My husband has been taking a liver health supplement called "Sisu Bao Gan Wan" from Wuzhou Pharmaceutical for a long time.
The instructions indicate that it is a dietary supplement.
Is it safe for long-term use, or could it potentially burden the liver?
4.
My husband regularly donated blood ten years ago, and all tests were normal.
Does this indicate that he likely contracted hepatitis C around that time?
5.
How long can the hepatitis C virus survive outside the human body in the air?
6.
In the future, is there a possibility of developing better medications than the current interferon treatments for hepatitis C that could reduce side effects and improve cure rates?
I sincerely appreciate your time in answering these questions.
Thank you very much.

Sally, 40~49 year old female. Ask Date: 2006/10/23

Dr. Xu Jinchuan reply Gastroenterology and Hepatology


Hello, Doctor: My husband donated blood about ten years ago, and afterward, the blood donation center sent a notification stating that he tested positive for hepatitis C surface antibodies.
Since then, his GOT and GPT levels have consistently been around 20.
He does not smoke or drink alcohol and maintains a regular lifestyle.
We cannot think of any source of infection.
I have undergone several health checks, all of which have been normal.
Doctors have said that my husband does not need treatment and should just be monitored.

I have a few questions for you:
1.
Is it possible for the blood donation center to make a mistake? Could it be that my husband was infected with hepatitis C but has since recovered? # The blood donation center conducts mass screenings, so there is a possibility of false positives.
I recommend that he undergoes a re-evaluation at a liver clinic for peace of mind.

2.
We have two children.
What is the likelihood of them being infected in daily life? I have heard that the viral load of hepatitis C in the blood is generally low, making it less contagious than hepatitis B.
Is this correct? I have also read that the likelihood of children being infected with hepatitis C is lower than that of adults.
# This is indeed true; children are generally at a lower risk of contracting hepatitis C in their daily lives.

3.
My husband has been taking a liver supplement called "Sisi Baogan Wan" from Wuzhou Pharmaceutical.
The instructions indicate that it is a dietary supplement.
Is it safe for long-term use? Could it potentially burden the liver? # Yes, it is safe and will not cause harm.

4.
My husband regularly donated blood ten years ago, and all tests were normal.
Does this indicate that he may have contracted hepatitis C around that time? # It is possible that he was infected earlier, but it could also be a recent infection.

5.
How long can the hepatitis C virus survive outside the human body in the air? # Some textbooks state that the hepatitis C virus can survive in the air for several hours to days.

6.
In the future, is there a possibility of developing better medications than the current interferon treatment for hepatitis C, which could reduce side effects and improve cure rates? # We hope so; this is indeed our goal.

Reply Date: 2006/10/23

More Info


Understanding Hepatitis C is crucial for both patients and their families, especially when it comes to diagnosis, transmission, and treatment options. Here are the answers to your questions based on the information provided and current medical knowledge.

1. Could the blood donation center have made a mistake?
It is possible, but unlikely. Blood donation centers follow strict protocols for testing. If your husband tested positive for anti-HCV antibodies, it indicates that he has been exposed to the Hepatitis C virus (HCV) at some point. However, it is also possible that he cleared the virus spontaneously, which occurs in about 15-45% of cases. This means that while he may have been infected, he no longer has an active infection, especially if his liver enzyme levels (GOT and GPT) are consistently low, as you mentioned.

2. What is the risk of transmission to your children?
Hepatitis C is primarily transmitted through blood-to-blood contact. The risk of transmission in a household setting is low, especially if there are no shared needles or exposure to blood. It is true that Hepatitis C is less contagious than Hepatitis B. Children are generally at a lower risk of contracting Hepatitis C compared to adults, primarily due to the modes of transmission being less common in everyday interactions. Maintaining good hygiene practices and avoiding sharing personal items that may have blood on them (like razors) can further reduce any risk.

3. Is it safe for your husband to take the liver health supplement?
While many liver health supplements claim to support liver function, it is essential to consult with a healthcare provider before starting any long-term supplementation. Some supplements can interact with medications or may not be beneficial for everyone. If your husband is taking a product labeled as a dietary supplement, it is crucial to ensure it does not contain harmful ingredients that could burden the liver, especially if he has a history of liver issues.

4. Does regular blood donation indicate that your husband was infected with Hepatitis C around ten years ago?
If your husband has been donating blood regularly and has only recently tested positive for anti-HCV antibodies, it is likely that he contracted the virus around the time of the positive test. However, the exact timing of infection can be difficult to determine without further testing, such as HCV RNA testing, which would confirm if the virus is currently active.

5. How long can the Hepatitis C virus survive outside the body?
HCV can survive outside the body for up to several weeks, depending on the environment. However, it is not transmitted through casual contact or airborne routes. The virus is primarily transmitted through direct blood exposure.

6. Are there advancements in treatment for Hepatitis C?
Yes, there have been significant advancements in the treatment of Hepatitis C in recent years. Direct-acting antiviral (DAA) therapies have revolutionized the treatment landscape, offering higher cure rates (over 95%) with fewer side effects compared to older treatments like interferon and ribavirin. Ongoing research continues to explore new medications that may further improve treatment efficacy and reduce side effects.

In conclusion, it is essential for your husband to continue regular follow-ups with his healthcare provider to monitor his liver health and any potential need for treatment. If there are any concerns about his health or the supplements he is taking, discussing these with a physician is advisable. Regular check-ups and blood tests will help ensure that any changes in his condition are promptly addressed.

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