Pulmonary Fibrous Granulomas: Risks and Treatment Options - Pulmonology

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Pulmonary fibrous hamartoma


Hello Dr.
Zhou,
Four years ago, I was diagnosed with pulmonary tuberculosis and have since recovered after treatment.
Recently, after undergoing blood tests and a chest X-ray, it was found that there is a fibrous granuloma in the upper left lung.
Additionally, my mean corpuscular volume (MCV) is 68, and my red blood cell count is 5.94 (other values such as white blood cell count, hemoglobin, and platelet count are within the normal range).

I would like to ask the doctor:
1.
What is a fibrous granuloma? What are the potential risks? Is treatment necessary?
2.
Are there any issues with my blood results?
Thank you!

Wangyou Y, 30~39 year old female. Ask Date: 2006/12/27

Dr. Zhou Ziguang reply Pulmonology


Hello:
1.
General fibrous granuloma is a change left by previous inflammation or injury.
It should be compared with the original X-ray to confirm whether it is indeed an old lesion; otherwise, further intervention may be necessary.
Please discuss this with the original treating physician.

2.
The mean corpuscular volume (MCV) of 68 is low, which may indicate the possibility of thalassemia, leading to a compensatory increase in red blood cell count.
Please consult with a hematologist for confirmation.

Sincerely,
Dr.
Chou Tzu-Kuang, Attending Physician, General Internal Medicine

Reply Date: 2006/12/27

More Info


Dear Patient,
Thank you for your inquiry regarding pulmonary fibrous granulomas, especially in the context of your previous history of tuberculosis. I appreciate your concerns, and I will address your questions in detail.

1. What is a fibrous granuloma? What are its risks? Does it require treatment?
A fibrous granuloma is a type of lesion that forms in the lungs as a result of chronic inflammation. It is often a response to infections, such as tuberculosis, or other irritants that cause the immune system to react. In your case, the granuloma may be a residual effect of your past tuberculosis infection. Granulomas are typically composed of a collection of immune cells, including macrophages, which can fuse to form multinucleated giant cells.
The risks associated with fibrous granulomas largely depend on their size, location, and whether they are symptomatic. Most granulomas are benign and do not pose significant health risks. They often do not require treatment unless they are causing symptoms or there is uncertainty about their nature. In many cases, they are discovered incidentally during imaging studies and are monitored over time. Regular follow-up with imaging, such as chest X-rays or CT scans, is usually recommended to ensure that there are no changes in size or characteristics that might suggest malignancy or other complications.

2. What are the implications of your blood test results?
Your blood test results indicate an average red blood cell volume (MCV) of 68, which is below the normal range (typically 80-100 fL). This condition is known as microcytic anemia, which can be caused by several factors, including iron deficiency, chronic disease, or thalassemia. The red blood cell count of 5.94 is within the normal range, but the low MCV suggests that the red blood cells are smaller than average, which can affect oxygen transport in the body.

Given that your white blood cell count, hemoglobin, and platelet counts are within normal limits, it is essential to investigate the cause of the low MCV further. Iron studies, including serum ferritin, serum iron, and total iron-binding capacity (TIBC), can help determine if iron deficiency is the underlying issue. If iron deficiency is confirmed, dietary modifications or iron supplementation may be necessary.

In summary, while fibrous granulomas are generally benign and often do not require treatment, it is crucial to monitor them over time. Your blood test results indicate a potential issue with red blood cell production that warrants further investigation. I recommend discussing these results with your healthcare provider, who can guide you through the necessary steps for diagnosis and management.

Please feel free to reach out if you have more questions or need further clarification on any of these points. Your health and well-being are of utmost importance, and I encourage you to stay proactive in your follow-up care.

Best regards,
Doctor Q&A Teams

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