Effects of Levonorgestrel on Pregnancy: Safety and Classification - Pharmacology

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Taking levonorgestrel during pregnancy?


I am currently 6 weeks pregnant.
I took emergency contraception on December 24, 1995, and January 7, 1996.
Does this have any impact on the fetus? What pregnancy category does levonorgestrel belong to? Thank you!

Li, 30~39 year old female. Ask Date: 2007/02/05

Dr. Hou Fangmin reply Pharmacology


Hello: Medications during pregnancy are classified into five categories.
The following are the classifications for medications used by pregnant women:
A - There is no evidence to suggest that it affects the fetus during early pregnancy.

B - Animal studies show no harm, but there is insufficient data on pregnant women.

C - Animal studies show harm, but there is a lack of well-controlled data on pregnant women.

D - It has been confirmed to be harmful to human fetuses, but may be used in emergency situations.

X - It has been confirmed to be harmful to human fetuses, and the risks clearly outweigh the benefits.
It is absolutely contraindicated for pregnant women.

The medication you are taking is classified as category X.
It is best for you to consult an obstetrician for an ultrasound examination and further guidance before making any decisions.
Is this response okay? Wishing you a beautiful baby! Bye!

Reply Date: 2007/02/05

More Info


Levonorgestrel is a synthetic progestin commonly used in emergency contraception, often referred to as the "morning-after pill." When considering its effects on pregnancy, particularly in the context of having taken it while already pregnant, it is essential to understand both its pharmacological classification and the implications for fetal development.

Firstly, Levonorgestrel is classified as a Category X medication in the context of pregnancy. This classification indicates that studies have demonstrated a risk to the fetus, and the potential risks involved in using the drug during pregnancy outweigh any possible benefits. Category X drugs are contraindicated in pregnancy, meaning they should not be used by pregnant women due to the potential for harm to the developing fetus.

In your case, having taken Levonorgestrel while already being six weeks pregnant raises concerns. While Levonorgestrel is primarily intended to prevent pregnancy by inhibiting ovulation or preventing fertilization, its use during an established pregnancy is not recommended. The concern is that, although Levonorgestrel is not intended to terminate an existing pregnancy, its effects on a developing embryo are not fully understood, and there is a possibility of adverse outcomes.

Research on the effects of Levonorgestrel during pregnancy is limited, but some studies suggest that exposure to progestins in early pregnancy may be associated with certain risks, including potential developmental issues. However, it is crucial to note that the majority of available data indicates that the risk of significant harm is relatively low, especially if the exposure occurred early in the pregnancy. The most critical factor is the timing of the exposure and the overall health of the pregnancy.

If you have concerns about the potential effects of Levonorgestrel on your pregnancy, it is highly advisable to consult with a healthcare provider, preferably an obstetrician or a maternal-fetal medicine specialist. They can provide personalized guidance based on your specific situation, including monitoring the pregnancy through ultrasound and other assessments to ensure the health of both you and your baby.

In summary, Levonorgestrel is classified as a Category X drug, indicating it is contraindicated during pregnancy. While there may be concerns regarding its use during an established pregnancy, the actual risk of significant harm may be low. Nevertheless, it is essential to seek medical advice to assess the situation and ensure appropriate monitoring and care throughout your pregnancy. Your healthcare provider will be the best resource for addressing any specific concerns and providing reassurance as you move forward.

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