Hepatitis C Treatment: Key Questions and Considerations - Gastroenterology and Hepatology

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Treatment for Hepatitis C


Hello Dr.
Lee,
I have a few questions I would like to ask:
1.
After about six months of testing, I have been diagnosed with hepatitis C (the doctor only mentioned a value of 205, so it's unclear whether it's acute or chronic).
My first liver function test showed GOT and GPT levels at 142, and the second test showed around 50.
Should I start interferon treatment? When would be the appropriate time for treatment?
2.
What are the side effects of interferon, and are there other medications that can help alleviate these symptoms?
3.
I have been advised that the out-of-pocket cost for one treatment course is approximately how much?
Thank you!

A-Qin, 40~49 year old female. Ask Date: 2007/05/31

Dr. Li Xuanshu reply Gastroenterology and Hepatology


Hello! The current treatment principle for hepatitis C is that liver inflammation, indicated by GPT levels, exceeds twice the upper limit of normal values (the National Health Insurance Administration also requires a liver biopsy).
The current condition can still be monitored, but I wonder if you have checked HCV RNA? Common side effects of interferon include headaches, muscle aches, and fever, which can be alleviated with antipyretics; other side effects will depend on their severity.
If financial considerations are not an issue, the out-of-pocket cost is approximately 160,000 to 180,000 NTD.

Reply Date: 2007/05/31

More Info


Hepatitis C is a viral infection that primarily affects the liver and can lead to serious health issues, including liver cirrhosis and liver cancer if left untreated. Understanding the treatment options, potential side effects, and financial implications is crucial for patients navigating this condition.
1. Diagnosis and Timing of Treatment: Based on your inquiry, it seems you have been diagnosed with Hepatitis C, and your liver function tests (GOT and GPT) have shown significant fluctuations. The initial high levels of these enzymes indicate liver inflammation, which can be a result of the Hepatitis C virus. The decrease in enzyme levels to around 50 suggests some improvement, but it's essential to evaluate the overall liver function and the presence of the virus.
The decision to start treatment with interferon (often combined with ribavirin) depends on several factors, including the type of Hepatitis C virus you have, the extent of liver damage (fibrosis stage), and your overall health. Generally, treatment is recommended for patients with chronic Hepatitis C, especially if there is evidence of significant liver damage or if the viral load is high. If your liver function tests are improving and you have no significant fibrosis, your doctor may suggest monitoring your condition before starting treatment.
2. Side Effects of Interferon and Management: Interferon therapy can have various side effects, including flu-like symptoms, fatigue, depression, and changes in blood counts (like low white blood cells and platelets). While there are no specific medications to completely eliminate these side effects, supportive care can help manage them. For instance, medications for pain relief, anti-nausea drugs, and mental health support can be beneficial. It’s crucial to communicate with your healthcare provider about any side effects you experience, as they can adjust your treatment plan accordingly.

3. Cost of Treatment: The cost of Hepatitis C treatment can vary significantly based on the specific medications used and whether you have insurance coverage. Interferon and ribavirin treatment can be expensive, often ranging from $12,000 to $30,000 for a full course, depending on the duration and specific regimen. Some newer direct-acting antiviral (DAA) therapies are available that have shown higher cure rates and fewer side effects, but they can also be costly. It’s advisable to consult with your healthcare provider and insurance company to understand your options and any potential financial assistance programs that may be available.

In addition to medical treatment, lifestyle modifications can play a significant role in managing Hepatitis C. Maintaining a balanced diet, avoiding alcohol, and ensuring adequate hydration can support liver health. Regular follow-ups with your healthcare provider are essential to monitor liver function and adjust treatment as necessary.

Lastly, it’s important to address any psychological impacts of living with Hepatitis C. Many patients experience anxiety or depression related to their diagnosis. Seeking support from mental health professionals or support groups can be beneficial in coping with these feelings.

In conclusion, navigating Hepatitis C treatment involves careful consideration of medical, financial, and emotional factors. Open communication with your healthcare provider is key to making informed decisions about your treatment plan.

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