Heart Pain from Risperdal and Coffee: What You Need to Know - Cardiology

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Experiencing heart pain after taking Risperdal and drinking coffee?


Dear Pharmacist,
I previously took half a tablet of RISPERDAL, which is an orange pill, with a dosage of 2 mg per full tablet.
Since many antidepressants I tried were ineffective, my doctor switched me to this medication.
I also requested medication to help me focus, so the doctor prescribed me two tablets of Caffeine per day, along with two tablets of INDERAL.
The effects were good, and I experienced no side effects.
Later, I told my doctor that the focus medication didn't seem to work much, and she mentioned that the interactions were quite complex and suggested discontinuing it.
After stopping, I experienced severe drowsiness.
When I drink coffee, I have persistent heart pain, but if I don’t drink it, I feel sleepy.
I believe in not relying on medication, so I stopped taking it.
Now, I am drinking 50 cc of red wine to maintain my heart health.
When I feel uncomfortable again, I think I shouldn’t push through it.
I want to start taking medication again; can I continue drinking red wine? Will it put too much strain on my liver and heart?
Q2: Was my previous lack of sleepiness due to the Caffeine? I used to have heart pain (mitral valve prolapse); will taking this medication worsen my condition?

Xiao Xiao, 10~19 year old female. Ask Date: 2007/12/10

Dr. He Dongjin reply Cardiology


If the drowsiness from this medication is significant, it's best to avoid taking it if possible.
If you do take it, you may need to consider using a stimulant and discuss this with your doctor.

Reply Date: 2007/12/10

More Info


When it comes to managing heart pain while taking medications like Risperdal and consuming caffeine, it's essential to understand the interactions between these substances and their effects on your body, especially considering your history of mitral valve prolapse (MVP).
Risperdal (risperidone) is an atypical antipsychotic often prescribed for conditions like schizophrenia, bipolar disorder, and severe depression. While it can be effective for these conditions, it may also cause side effects, including sedation and potential cardiovascular effects. Caffeine, a stimulant found in coffee and many other beverages, can increase heart rate and blood pressure, which may exacerbate any underlying heart conditions, including MVP.

Your experience of heart pain after consuming caffeine could be attributed to several factors. Caffeine can lead to increased heart rate (tachycardia) and may provoke palpitations, especially in individuals with pre-existing heart conditions. The interaction between caffeine and Risperdal can be complex; while Risperdal may help manage certain psychiatric symptoms, it can also contribute to feelings of sedation or fatigue, which might explain your increased sleepiness after stopping caffeine.

Regarding your question about drinking red wine, moderation is key. While some studies suggest that moderate alcohol consumption may have cardiovascular benefits, excessive drinking can lead to increased heart strain and potential liver damage, especially when combined with medications. The liver metabolizes both alcohol and many medications, which can lead to increased toxicity or reduced efficacy of the drugs. Therefore, if you choose to consume red wine, it’s crucial to do so in moderation and consult your healthcare provider about your specific situation.

As for your concern about whether caffeine was the reason for your previous lack of sleepiness, it’s possible. Caffeine is a central nervous system stimulant that can temporarily ward off drowsiness and increase alertness. However, once its effects wear off, you may experience a rebound effect, leading to increased fatigue or sleepiness.
Given your history of mitral valve prolapse, it’s essential to be cautious with caffeine intake. While mild MVP typically does not lead to severe complications, it can be associated with palpitations and discomfort, particularly when combined with stimulants. If you experience significant heart pain or discomfort, it’s advisable to seek medical attention to rule out any serious issues.

In summary, balancing medication and dietary choices requires careful consideration, especially with a history of heart conditions. It’s crucial to communicate openly with your healthcare provider about your symptoms, medication regimen, and lifestyle choices, including caffeine and alcohol consumption. They can provide personalized advice and adjustments to your treatment plan to ensure your safety and well-being. If you continue to experience heart pain or other concerning symptoms, do not hesitate to seek medical evaluation.

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