Dry Cough in Hypertension Patients: Causes and Solutions - Internal Medicine

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Antihypertensive medications and dry cough?


Current medications include: 1.
Tenormin 100 mg tablet (Atenolol) 2.
Posterisan Forte ointment 10 g 3.
Prozac 20 mg dispersible tablet (Fluoxetine) 4.
Renitec tablet 5 mg (Enalapril) 5.
Moduretic tablet (Amiloride and Hydrochlorothiazide) 6.
Bokey E-M capsule 100 mg (Bacillus subtilis).
The patient is a 63-year-old female who had her tonsils removed in childhood and was previously hospitalized for pulmonary embolism.
She has been taking antihypertensive medications long-term without experiencing a dry cough, but has recently developed a dry cough.

Is it possible that the cough is related to her tonsillectomy or the antihypertensive medications? Can she take Glycyrrhiza and Opium combination tablets (Glycyrrhiza 0.48 + Opium 2.5) for cough relief, or should her medications be changed? Thank you!

NICOLE, 60~69 year old female. Ask Date: 2008/03/20

Dr. Zhong Weisheng reply Internal Medicine


The dry cough mentioned in your letter is most likely caused by the medication Renitec (Enalapril) 5 mg.
It is recommended to discontinue this medication.
If blood pressure increases, you may consider adding a non-angiotensin-converting enzyme inhibitor.
Thank you for your letter, and I wish you good health.
Dr.
Chung Wei-Sheng.

Reply Date: 2008/03/20

More Info


Dry cough in patients with hypertension can be a perplexing issue, especially when it arises after years of stable medication use. In your case, you are taking several medications, including Tenormin (Atenolol), Renitec (Enalapril), and others, which can potentially contribute to the development of a dry cough.
Firstly, it's important to understand that certain classes of antihypertensive medications, particularly ACE inhibitors like Renitec (Enalapril), are known to cause a dry cough in some patients. This side effect occurs in approximately 20% of individuals taking ACE inhibitors. The cough is thought to be related to the accumulation of bradykinin, a peptide that can cause irritation in the respiratory tract. If you have recently started or increased the dosage of Renitec, this could explain the onset of your dry cough.

On the other hand, the history of tonsillectomy (removal of the tonsils) is less likely to be a direct cause of your dry cough. While tonsils play a role in the immune response, their removal does not typically lead to chronic cough. However, it is possible that the absence of tonsils may alter your immune response to respiratory infections, potentially making you more susceptible to cough-inducing irritants.

Given your symptoms, it is advisable to consider the following steps:
1. Medication Review: Since you suspect that your cough may be related to Renitec, it would be prudent to discuss this with your healthcare provider. They may consider switching you to an alternative antihypertensive medication, such as an Angiotensin II receptor blocker (ARB), which generally has a lower incidence of cough as a side effect.

2. Symptomatic Relief: Regarding the use of glycyrrhiza and opium tablets (甘草片), these can provide symptomatic relief for coughs, but they should be used cautiously. Glycyrrhiza can have side effects, especially in individuals with hypertension, as it can lead to sodium retention and potassium loss, potentially exacerbating blood pressure issues. Always consult your physician before adding any over-the-counter remedies to your regimen.

3. Further Evaluation: If the cough persists despite medication adjustments, or if you experience additional symptoms such as shortness of breath, wheezing, or chest pain, further evaluation may be warranted. This could include pulmonary function tests or imaging studies to rule out other respiratory conditions.

4. Lifestyle Modifications: In addition to medication management, consider lifestyle changes that can help alleviate cough symptoms. Staying hydrated, using a humidifier, and avoiding irritants such as smoke or strong odors can be beneficial.

5. Regular Monitoring: Since you have a history of pulmonary embolism, it is essential to monitor your respiratory health closely. Regular follow-ups with your healthcare provider can help ensure that any changes in your condition are addressed promptly.

In summary, while your dry cough may be related to your antihypertensive medication, particularly Renitec, it is essential to consult with your healthcare provider for a comprehensive evaluation and management plan. They can help determine the best course of action, including potential medication changes and symptomatic relief strategies.

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