Managing Cough and Throat Irritation from Blood Pressure Medications - Cardiology

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Cardiovascular disease


Dr.
Zhong: Hello, I have been taking high blood pressure medication Encine (Aspirin 100mg) and Sintec (5mg) for about 20 days, and I have developed a dry cough that is persistent and my throat is itchy, making it very uncomfortable.
I informed my primary care physician, who mentioned that 20% of patients may experience coughing as a side effect.
Therefore, the doctor switched my medication to Encine (Aspirin 100mg) and Cozaar F.C.
TAB (50mg), but after taking it for 3 days, I still have an itchy throat and persistent cough.
I would like to ask Dr.
Zhong if I should go back to the clinic to change my medication since I have 28 days' worth of medication left.
Is this a side effect of the medication, or could it be a cold? However, it doesn't feel like a cold.
What should I do? Thank you!

Lin Tai Tai, 50~59 year old female. Ask Date: 2002/12/07

Dr. Zhong Yuxun reply Cardiology


Dear Mrs.
Lin,
Sintec is classified as an Angiotensin-Converting Enzyme Inhibitor (ACEI), and approximately 30% of Chinese individuals may experience a dry cough as a side effect.
Cozaar, on the other hand, is an Angiotensin II Receptor Blocker (ARB) and has very few side effects, although there have been reports of a small number of patients experiencing cough after taking it.
If you suspect a medication side effect, it may be advisable to consider switching medications.
Additionally, there are four major classes of antihypertensive medications available for you to choose from.
You may discuss this with your physician, as there are a total of six classes of antihypertensive drugs, comprising dozens of medications!
Wishing you good health,
Dr.
Chung Yu-Hsuan, Director of Cardiology, Taoyuan Hospital, Department of Health, Executive Yuan

Reply Date: 2002/12/07

More Info


Managing cough and throat irritation as side effects of blood pressure medications can be quite challenging, especially when patients are unsure whether their symptoms are due to the medication or an underlying condition such as a cold. In your case, you have been experiencing a persistent dry cough and throat irritation after starting Sintec (an ACE inhibitor) and later switching to Cozaar (an ARB), along with Aspirin.
First, it’s important to understand the mechanisms behind these medications and their potential side effects. ACE inhibitors, like Sintec, are known to cause a dry cough in a subset of patients—approximately 20% of individuals may experience this side effect. This occurs due to the accumulation of bradykinin, a peptide that can lead to increased sensitivity in the respiratory tract, resulting in a cough reflex. On the other hand, ARBs like Cozaar are generally better tolerated and have a lower incidence of cough as a side effect. However, there are still reports of some patients experiencing cough with ARBs, albeit less frequently.

Given that you have switched medications and are still experiencing throat irritation and cough, it is essential to consider a few possibilities. First, it could indeed be a continuation of the side effects from the previous medication, or it could be a new reaction to Cozaar, albeit less common. Additionally, environmental factors, allergies, or even a viral infection could contribute to your symptoms. Since you mentioned that it doesn't feel like a typical cold, it might be more related to the medication.

In terms of management, here are some steps you can consider:
1. Consult Your Physician: Since your symptoms have persisted despite changing medications, it would be prudent to follow up with your healthcare provider. They may consider switching you to a different class of antihypertensive medications that are less likely to cause cough, such as calcium channel blockers or diuretics.

2. Symptomatic Relief: In the meantime, you might find relief from throat irritation by using throat lozenges, warm saltwater gargles, or humidifiers to moisten the air. Over-the-counter antihistamines may also help if your symptoms are related to allergies.

3. Monitoring Symptoms: Keep a record of your symptoms, noting any changes or patterns. This information can be valuable for your healthcare provider in determining the best course of action.

4. Consider Other Causes: If your cough persists, it may be worthwhile to investigate other potential causes, such as gastroesophageal reflux disease (GERD), which can also lead to throat irritation and cough.

5. Avoid Irritants: Stay away from known irritants such as smoke, strong odors, and allergens that could exacerbate your symptoms.

In summary, while the cough and throat irritation you are experiencing may be related to your blood pressure medications, it is essential to consult with your healthcare provider for a thorough evaluation and potential medication adjustment. They can help determine whether your symptoms are indeed a side effect of the medication or if another underlying issue needs to be addressed. Your health and comfort are paramount, and there are various options available to manage your blood pressure without compromising your quality of life.

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